218 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
April 2023 in “Journal of Investigative Dermatology” This study found that PX-12 inhibited the NLRP3 inflammasome and reduced psoriasis-like symptoms in a mouse model, suggesting its potential as a treatment for psoriasis.
4 citations
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September 2021 in “Medical Lasers” This review reports that low-level laser therapy may effectively prevent and alleviate oral mucositis from chemotherapy, supporting its use as a viable treatment option.
This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.
April 2012 in “The FASEB Journal” In this study, researchers observed that knocking down the LPA 4 receptor in zebrafish embryos led to vascular and lymph vessel development abnormalities, including edema and decreased heartbeats.
33 citations
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October 2016 in “Photomedicine and laser surgery” This review discusses the development of IPL devices, highlights their established cosmetic uses, such as treating vascular and pigmented lesions, and suggests potential expansion into more effective combination therapies.
5 citations
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August 2025 in “Drug Delivery and Translational Research” This review discusses lipid-polymer hybrid nanoparticles for dermatological applications, outlining their structural and formulation advancements, but reports no new clinical results and calls for further research on their therapeutic potential.
January 2023 in “Figshare” This meta-analysis found that a combination of clobetasol, hydroxychloroquine, and N-acetylcysteine may be the most effective treatment approach for lichen planopilaris compared to other therapies.
15 citations
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April 2020 in “Journal of The American Academy of Dermatology” This article discusses the challenges of treating lichen planopilaris, reviews various therapeutic options including minoxidil, and reports no new clinical findings.
91 citations
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May 2003 in “American Journal of Pathology” This study found that prolactin and its receptor are expressed in the murine hair follicle epithelium, influencing hair cycle phases by down-regulating keratinocyte proliferation during anagen and inducing premature catagen.
194 citations
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November 2006 in “Science” This study identified a gene mutation in the LIPH gene associated with inherited hair loss and hair growth defects in certain populations, suggesting lipase H plays a role in hair development.
July 2025 in “Cell & Bioscience” Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.
This study conducted a comparative analysis of platelet rich plasma and low level laser therapy for androgenetic alopecia but does not present new clinical findings.
1 citations
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November 2024 in “Cutis” PLLA injections can cause hair loss and skin issues.
May 2023 in “Pharmaceuticals” In this in silico study, researchers analyzed nonsynonymous SNPs in the LIPH gene linked to hypotrichosis and identified three potentially harmful variants (W108R, C246S, and H248N) out of 215 total, using sequence- and architecture-based bioinformatics techniques to differentiate between harmful and benign SNPs.
1 citations
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January 2016 in “Journal of gastrointestinal & digestive system” The researchers reported that the SAGI PGP procedure resulted in excess weight loss of over 90% in the first year and normalized blood sugar levels without medication among diabetic patients by the first month post-operation.
136 citations
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April 2013 in “Clinical Cancer Research” The study found that IPI-926 was well tolerated up to 160 mg once daily for 28-day cycles and showed activity as a single-agent treatment in Hedgehog pathway inhibitor-naïve patients with basal cell carcinoma.
10 citations
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June 2019 in “Case reports in dermatology” This paper presents a case of a young male with linear and annular lupus panniculitis of the scalp, detailing trichoscopic findings and their correlation with histopathological features, but reports no new generalizable results.
433 citations
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April 2015 in “Photomedicine and laser surgery” This editorial discusses the terminology and distinctions between Low-Level Light/Laser Therapy and Photobiomodulation Therapy but reports no new clinical findings.
February 2009 in “Journal of The American Academy of Dermatology” This study suggests that fractional infrared technology may effectively improve cervical skin laxity by enhancing dermal thickness without adverse effects in a small pilot group.
1 citations
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August 2022 in “JAAD case reports” This review discusses current treatments for cicatricial alopecia focused on reducing inflammation to prevent further hair loss and suggests auxiliary therapies to improve the appearance of remaining hair, without reporting new clinical results.
2 citations
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June 2020 in “Dermatology and therapy” In this case report, narrowband-UVB phototherapy successfully treated a rare instance of Graham Little-Piccardi-Lassueur syndrome, a variant of lichen planopilaris, as investigated through non-invasive imaging techniques.
February 2023 in “Journal of dermatology” This letter reports the first known Japanese case of autosomal recessive woolly hair/hypotrichosis with compound heterozygous mutations in the LIPH gene.
26 citations
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April 1999 in “Dermatologic Clinics” This article reviews the basics of hair follicle biology, laser/tissue interactions, and hirsutism and hypertrichosis causes, discussing the long-pulsed alexandrite laser's role in hair reduction without reporting new clinical results.
2 citations
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March 2016 in “The Journal of Dermatology” The researchers reported that the facial Psoriasis Log-based Area and Severity Index (fPLASI) more reliably and sensitively captured clinical improvement in facial psoriasis than the existing facial Psoriasis Area and Severity Index (fPASI).
July 2024 in “Journal of Investigative Dermatology” PP405 may help hair growth by activating hair follicle stem cells.
September 2021 in “Hair transplant forum international” In this study, the P&P Hairline Laser, a hands-free laser-assisted device, was found to produce smoother and more symmetrical hairlines compared to traditional handheld laser devices.
September 2011 in “Urology” This study explores the clinical significance of the intravesical prostatic protrusion/prostate volume ratio in diagnosing bladder outlet obstruction but reports no new results.
May 2024 in “JAAD Case Reports” This case report describes a 29-year-old man with a year-long non-itchy skin eruption and hair loss, with distinct papules and plaques across his scalp, beard, body, and suprapubic regions, but no systemic symptoms or family history of autoimmune disease.
4 citations
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October 2023 in “Dermatology” In this study, a network meta-analysis found that treating lichen planopilaris with a combination of clobetasol, hydroxychloroquine, and N-acetylcysteine was the most effective approach, while cyclosporine, methotrexate, and some other treatments were less effective compared to hydroxychloroquine.