The Investigation of LPA4 Functions in Zebrafish

The study investigated the role of the LPA 4 receptor in zebrafish, which is structurally distinct from LPA 1–3. By using LPA 4 morpholino microinjection on one-cell stage zebrafish embryos, researchers observed several phenotypes, including edema around the pericardial region, decreased heartbeats, slowed blood flow, and a slight decrease in intersegmental vessel numbers. These findings suggested that LPA 4 played a role in regulating blood and lymph vessel development in zebrafish.