TLDR LSD1 is crucial for regenerating hair cells in zebrafish.
The study examined the role of LSD1, a histone demethylase, in the regeneration of hair cells in zebrafish, finding that LSD1 was essential for this process. It suggested that LSD1 might be involved in the epigenetic regulation during hair cell development, potentially influencing molecular pathways and genetic interactions. This research offered insights that could have been relevant for creating therapeutic strategies for hair cell loss in other species.
20 citations
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January 2013 in “Cell & Bioscience” Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.
47 citations
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July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
100 citations
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November 2017 in “EMBO Reports” Metabolic signals and cell shape influence how cells develop and change.
132 citations
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August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
1 citations
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January 2011 in “Springer eBooks” Histone demethylases play a key role in the development of many diseases and may be targets for treatment.
