TLDR Zebrafish help understand genetic causes of skin pigment disorders like albinism.
The study used zebrafish to investigate hereditary pigmentary disorders like Dowling-Degos disease and oculocutaneous albinism due to their genetic similarities with humans. It found that mutations in genes such as POFUT1 and PSENEN caused hypopigmentation and abnormal melanin distribution in zebrafish, reflecting human symptoms. The research demonstrated that zebrafish are valuable for understanding the genetic and molecular mechanisms of these disorders. It also highlighted the role of thyroid hormones in melanogenesis, with effects varying by sex and pigment cell lineage, suggesting the need for more zebrafish models to explore pigment cell development and disease pathogenesis.
87 citations
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March 2017 in “Journal of Clinical Investigation” PSENEN gene mutations can cause both Dowling-Degos disease and acne inversa.
99 citations
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March 2013 in “Journal of Investigative Dermatology” Mutations in the ABCB6 gene cause Dyschromatosis Universalis Hereditaria.
59 citations
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November 2002 in “Pediatric Dermatology” A 19-month-old Saudi girl had a rare skin condition with no other defects, and her family was unaffected.
87 citations
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March 2017 in “Journal of Clinical Investigation” PSENEN gene mutations can cause both Dowling-Degos disease and acne inversa.
15 citations
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February 2015 in “Cell & tissue research/Cell and tissue research” P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.
August 2024 in “Applied Sciences” Plant extracts may help prevent or reverse hair graying.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” Gray hair can potentially be managed or reversed with treatments that boost melanin production and address nutritional deficiencies.
41 citations
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December 2018 in “Experimental Dermatology” Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.
