Iron–Skin Axis: Exploring the Interplay Between Iron Homeostasis and Skin Disorders

    October 2025 in “ Journal of Investigative Dermatology ”
    Doha Chrayteh, Sophie Vaulont, Carole Peyssonnaux
    Studysummary This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.
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    Research cited in this study 11

    1. Regulation Of Epidermal Ferritin Expression Influences Systemic Iron Homeostasis Journal of Investigative Dermatology · 2023
    2. Skin Manifestations Associated with Systemic Diseases – Part II Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2021
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    5. Iron Plays a Certain Role in Patterned Hair Loss Journal of Korean Medical Science · 2013
    6. Growth Retardation and Hair Loss in Transgenic Mice Overexpressing Human H-Ferritin Gene Transgenic Research · 2012
    7. Iron Deficiency in Female Pattern Hair Loss, Chronic Telogen Effluvium, and Control Groups Journal of The American Academy of Dermatology · 2010
    8. Iron Deficiency and Diffuse Nonscarring Scalp Alopecia in Women: More Pieces to the Puzzle Journal of The American Academy of Dermatology · 2010
    9. Decreased Serum Ferritin Is Associated With Alopecia in Women Journal of Investigative Dermatology · 2003
    10. There Is No Clear Association Between Low Serum Ferritin And Chronic Diffuse Telogen Hair Loss British Journal of Dermatology · 2002
    11. Causes of Hair Loss and Developments in Hair Rejuvenation International Journal of Cosmetic Science · 2002