Iron Deficiency in Immune-Mediated Inflammatory Skin Diseases: A Missing Link Between Systemic Inflammation, Immunometabolism, and Disease Burden

    March 2026 in “ Cells ”
    Emilia Kucharczyk, Klara Andrzejczak, Karol Biliński … Małgorzata Ponikowska
    Studysummary This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.
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    Research cited in this study 8

    1. Iron–Skin Axis: Exploring the Interplay Between Iron Homeostasis and Skin Disorders Journal of Investigative Dermatology · 2025
    2. Hypothesis: Platelet-Rich Plasma as an Adjunct Therapy for Eczema Targeting Inflammation, Skin Barrier Repair, and Chronic Recurrence Frontiers in Immunology · 2025
    3. Zinc, Copper, and Iron in Selected Skin Diseases International journal of molecular sciences · 2024
    4. Iron Metabolism of the Skin: Recycling Versus Release Metabolites · 2023
    5. Regulation Of Epidermal Ferritin Expression Influences Systemic Iron Homeostasis Journal of Investigative Dermatology · 2023
    6. Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks Journal of Investigative Dermatology · 2021
    7. Biallelic HEPHL1 Variants Impair Ferroxidase Activity and Cause an Abnormal Hair Phenotype PLOS genetics · 2019
    8. Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis PeerJ · 2014