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    Glossary Keratin Genes

    segments of DNA that encode structural proteins for hair

    Keratin genes are segments of DNA that encode for keratin proteins, which are essential structural components of hair, skin, and nails. These genes play a crucial role in the strength and resilience of these tissues, and mutations in keratin genes can lead to various hair and skin disorders, including certain types of alopecia.

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    1. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    2. Keratin gene mutations in disorders of human skin and its appendages Archives of Biochemistry and Biophysics · 2010 · 185 citations
    3. A group of type I keratin genes on human chromosome 17: characterization and expression. Molecular and Cellular Biology · 1988 · 141 citations
    4. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    5. Regulation of Keratin Gene Expression in Hair Follicle Differentiation<sup>a</sup> Annals of the New York Academy of Sciences · 1991 · 98 citations
    6. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    7. Annotation of sheep keratin intermediate filament genes and their patterns of expression Experimental Dermatology · 2011 · 83 citations
    8. A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012 · 78 citations
    9. Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert. 2004 · 62 citations
    10. A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21. Journal of Medical Genetics · 1994 · 61 citations
    11. Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005 · 58 citations
    12. Human KAP Genes, Only the Half of it? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes 2005 · 53 citations
    13. Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles Journal of Investigative Dermatology · 2016 · 50 citations
    14. Polymorphisms in the Human High Sulfur Hair Keratin-associated Protein 1, KAP1, Gene Family 2002 · 48 citations
    15. Krtap16, Characterization of a New Hair Keratin-associated Protein (KAP) Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13 Journal of Biological Chemistry · 2004 · 47 citations
    16. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    17. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988 · 38 citations
    18. The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes Journal of Biological Chemistry · 2008 · 35 citations
    19. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3 Genomics · 2004 · 34 citations
    20. Genes for Hair and Avian Keratins Annals of the New York Academy of Sciences · 1985 · 32 citations
    21. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    22. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms Molecular Biology Reports · 1995 · 21 citations
    23. The Microanatomy, Cell Replication, and Keratin Gene Expression of Hair Follicles during a Photoperiod-lnduced Growth Cycle in Sheep Cells tissues organs · 1995 · 20 citations
    24. A curated catalog of canine and equine keratin genes PLoS ONE · 2017 · 20 citations
    25. The organization of the keratin I and II gene clusters in placental mammals and marsupials show a striking similarity European Journal of Cell Biology · 2005 · 18 citations
    26. Association analysis of polymorphisms in six keratin genes with wool traits in sheep Asian-Australasian journal of animal sciences · 2017 · 17 citations
    27. The keratin proteins and genes of wool and hair. Adelaide Research & Scholarship (AR&S) (University of Adelaide) · 1996 · 15 citations
    28. Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin Skin pharmacology and physiology · 2015 · 11 citations
    29. [Genetic and biochemical aspects of keratin synthesis by hair follicles]. PubMed · 2007 · 10 citations
    30. Keratin Gene Expression Differences in Wool Follicles and Sequence Diversity of High Glycine-Tyrosine Keratin-Associated Proteins (Kaps) in Magra Sheep of India Journal of Natural Fibers · 2018 · 9 citations