Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in Mouse Skin

January 2015 in “ Skin pharmacology and physiology ”

Phuong Vu, Ryo Takatori, Toschitake Iwamoto, Y Akagi, Hideo Satsu, Mamoru Totsuka, Kazuhiro Chida, Kenji Satō, Makoto Shimizu

collagen peptides Prolyl-hydroxyproline Pro-Hyp keratin keratin-associated protein genes Krtap genes Krt genes epidermis development hair cycle keratinocytes fibroblasts CP

Studysummary In this study, oral collagen peptides increased certain gene expressions related to epidermis development and the hair cycle in hairless mice skin, suggesting potential links to hair health.

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In a study from 2015, researchers explored the impact of orally administered collagen peptides (CP) on skin gene expression in hairless mice and the effects of a collagen-derived dipeptide, prolyl-hydroxyproline (Pro-Hyp), on gene expression in a coculture of mouse skin cells. After 6 weeks of CP administration, there was an increase in the expression of genes related to epidermis development and the hair cycle, specifically Krtap and Krt genes. Additionally, Pro-Hyp was found to increase the expression of certain keratin-associated protein genes in keratinocytes when cocultured with fibroblasts, indicating that fibroblasts are necessary for this effect. This study suggests a connection between CP intake and the hair growth cycle.

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