Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in Mouse Skin

    January 2015 in “ Skin pharmacology and physiology ”
    Phuong Vu, Ryo Takatori, Toschitake Iwamoto, Y Akagi, Hideo Satsu, Mamoru Totsuka, Kazuhiro Chida, Kenji Satō, Makoto Shimizu
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    TLDR Eating collagen peptides may help with skin and hair growth.
    In a study from 2015, researchers explored the impact of orally administered collagen peptides (CP) on skin gene expression in hairless mice and the effects of a collagen-derived dipeptide, prolyl-hydroxyproline (Pro-Hyp), on gene expression in a coculture of mouse skin cells. After 6 weeks of CP administration, there was an increase in the expression of genes related to epidermis development and the hair cycle, specifically Krtap and Krt genes. Additionally, Pro-Hyp was found to increase the expression of certain keratin-associated protein genes in keratinocytes when cocultured with fibroblasts, indicating that fibroblasts are necessary for this effect. This study suggests a connection between CP intake and the hair growth cycle.
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