The Hair Loss Encyclopedia

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in Mouse Skin

January 2015 in “ Skin pharmacology and physiology ”

Phuong Vu, Ryo Takatori, Toschitake Iwamoto, Y Akagi, Hideo Satsu, Mamoru Totsuka, Kazuhiro Chida, Kenji Satō, Makoto Shimizu

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TLDR Eating collagen peptides may help with skin and hair growth.

In a study from 2015, researchers explored the impact of orally administered collagen peptides (CP) on skin gene expression in hairless mice and the effects of a collagen-derived dipeptide, prolyl-hydroxyproline (Pro-Hyp), on gene expression in a coculture of mouse skin cells. After 6 weeks of CP administration, there was an increase in the expression of genes related to epidermis development and the hair cycle, specifically Krtap and Krt genes. Additionally, Pro-Hyp was found to increase the expression of certain keratin-associated protein genes in keratinocytes when cocultured with fibroblasts, indicating that fibroblasts are necessary for this effect. This study suggests a connection between CP intake and the hair growth cycle.

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research Chrysanthemum Zawadskii Extract Induces Hair Growth by Stimulating the Proliferation and Differentiation of Hair Matrix

12 citations , May 2014 in “International Journal of Molecular Medicine”

Chrysanthemum zawadskii extract helps hair grow by stimulating hair cells.

research The Inductive Effect of Ginsenoside F2 on Hair Growth by Altering the WNT Signal Pathway in Telogen Mouse Skin

42 citations , May 2014 in “European Journal of Pharmacology”

Ginsenoside F2 from ginseng may increase hair growth better than standard treatments by affecting cell growth signals.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , October 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Brain And Muscle Arnt-Like Protein-1 (BMAL1) Controls Circadian Cell Proliferation And Susceptibility To UVB-Induced DNA Damage In The Epidermis

221 citations , July 2012 in “Proceedings of the National Academy of Sciences of the United States of America”

BMAL1 controls skin cell growth and UV damage risk, peaking at night.

research BMP Signaling in the Control of Skin Development and Hair Follicle Growth

165 citations , December 2004 in “Differentiation”

BMP signaling is crucial for skin and hair growth.

research The RAIG Family Member, GPRC5D, Is Associated With Hard-Keratinized Structures

64 citations , March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.