A Dietary Supplement Improves Age-Related Dermatological Changes: Observational, Anecdotal, Spontaneous Study

In a study from 2017, thirty-four patients were given a dietary supplement containing collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol®, and coenzyme Q10 twice daily for 12 weeks to assess its effects on age-related dermatological changes. The results showed significant improvements in skin hydration, Trans Epidermal Water Loss (TEWL), and elasticity in all tested areas, with p-values less than 0.01 and 0.001. Additionally, nail hardness in the index, middle, and ring fingers significantly increased (p < 0.001), and both the Hair Mass Index (HMI) and the Hair Breakage Index (HBI) were significantly reduced (p < 0.0001). The study concluded that the dietary supplement significantly improved age-related changes in skin, nails, and hair.