Supplementary Material For: Effects Of Food-Derived Collagen Peptides On The Expression Of Keratin And Keratin-Associated Protein Genes In The Mouse Skin

January 2017

Phuong Vu, R. Takatori, T. Iwamoto, Y Akagi, Hideo Satsu, Mamoru Totsuka, Kazuhiro Chida, Kazuhiro Sato, Makiko Shimizu

collagen peptides prolyl-hydroxyproline keratin keratin-associated protein Krtap genes Krt genes keratinocytes fibroblasts epidermis development hair cycle collagen Pro-Hyp

TLDR Collagen peptides may boost skin and hair-related gene expression.

The study investigated the effects of oral collagen peptides (CP) on gene expression in hairless mouse skin and the impact of the collagen-derived dipeptide prolyl-hydroxyproline (Pro-Hyp) on gene expression in a coculture of mouse skin keratinocytes and fibroblasts. After 6 weeks of CP administration, there was an increased expression of Krtap and Krt genes, which are associated with epidermis development and the hair cycle. Pro-Hyp also increased the expression of several Krtap genes in keratinocytes, but only in the presence of fibroblasts, indicating their essential role. This research provided new insights into how CP might influence the skin and hair cycle.

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