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    Glossary JAK inhibitor

    blocks enzymes involved in immune response and inflammation

    A JAK inhibitor, also known as a Janus kinase inhibitor or JAKi, is a type of medication that blocks the activity of Janus kinase enzymes. These enzymes play a crucial role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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    1. JAK inhibitors in dermatology: The promise of a new drug class Journal of the American Academy of Dermatology · 2017 · 355 citations
    2. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019 · 277 citations
    3. JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis Rheumatology · 2018 · 223 citations
    4. JAK inhibitors for alopecia areata: a systematic review and meta‐analysis 2019 · 130 citations
    5. JAK Inhibitors for Treatment of Alopecia Areata 2018 · 63 citations
    6. JAK inhibitors and alopecia areata Lancet · 2019 · 56 citations
    7. JAK-inhibitors in dermatology: current evidence and future applications Journal of dermatological treatment · 2018 · 45 citations
    8. A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021 · 40 citations
    9. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    10. The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies Frontiers in pharmacology · 2022 · 37 citations
    11. Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream Pharmaceutics · 2021 · 24 citations
    12. Inhibidores de JAK: usos en dermatología. Parte 1: generalidades, aplicaciones en vitíligo y en alopecia areata Actas Dermo-Sifiliográficas · 2020 · 20 citations
    13. Emerging drugs for alopecia areata: JAK inhibitors Expert opinion on emerging drugs · 2018 · 20 citations
    14. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    15. Simultaneous improvement of alopecia universalis and atopic dermatitis in a patient treated with a JAK inhibitor JAAD case reports · 2018 · 16 citations
    16. Under Development JAK Inhibitors for Dermatologic Diseases Mediterranean Journal of Rheumatology · 2020 · 14 citations
    17. JAK Inhibitors in the Treatment of Lichen Planopilaris Skin Appendage Disorders · 2023 · 12 citations
    18. Rebound effect associated with JAK inhibitor use in the treatment of alopecia areata Journal of the European Academy of Dermatology and Venereology · 2018 · 11 citations
    19. Predictors and Management of Inadequate Response to JAK Inhibitors in Alopecia Areata American Journal of Clinical Dermatology · 2024 · 11 citations
    20. Recalcitrant alopecia areata responsive to leflunomide and anthralin—Potentially undiscovered JAK/STAT inhibitors? Pediatric dermatology · 2018 · 11 citations
    21. Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata EBioMedicine · 2015 · 11 citations
    22. Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib—A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata Dermatology and therapy · 2023 · 9 citations
    23. JAK Inhibitors: A New Weapon in the Skin Care Providers' Arsenal. PubMed · 2023 · 8 citations
    24. Efficacy and safety of different JAK inhibitors in the treatment of alopecia areata: a network meta-analysis Frontiers in immunology · 2023 · 7 citations
    25. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    26. Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors Journal of autoimmunity · 2022 · 6 citations
    27. FDA approves Pfizer's JAK inhibitor for adolescents with alopecia areata hair loss Nature Medicine · 2023 · 4 citations
    28. The evaluation of JAK inhibitors on effect and safety in alopecia areata: a systematic review and meta-analysis of 2018 patients Frontiers in immunology · 2023 · 4 citations
    29. [JAK INHIBITORS FOR THE TREATMENT OF ALOPECIA AREATA]. PubMed · 2020 · 4 citations
    30. Real-world experience quantifying access to JAK inhibitor care for alopecia areata patients: a patient-centered survey study International Journal of Women’s Dermatology · 2024 · 3 citations