Treatment of Refractory Folliculitis Decalvans With the Topical JAK Inhibitor Tofacitinib

    September 2023 in “ Journal of the American Academy of Dermatology ”
    Katherine Holder, Christina L. Harview, Mitchell Gibbons, Marta VanBeek
    Image of study
    TLDR Topical tofacitinib helped a man with severe scalp condition after other treatments failed.
    A male patient in his 50s with refractory folliculitis decalvans (FD) of the scalp, unresponsive to various treatments including antibiotics, steroids, and surgical excision, experienced significant improvement after using topical tofacitinib, a Janus Kinase inhibitor (JAKi), twice daily. After four months, his FD became clinically quiescent, and he reported complete resolution of pain and draining sinus tracts. This case highlights the potential effectiveness of topical JAK inhibitors in treating FD, a condition that is typically difficult to manage with conventional therapies.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 52 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I tried salt water to stop the DHT itch

      in Treatment  60 upvotes 2 years ago
      Treating the itch associated with male pattern baldness, which is believed to be caused by DHT. Potential treatments discussed include salt water, finasteride, ketoconazole, and RU58841.

    Related Research

    6 / 6 results