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    Glossary Interfollicular Epidermal Stem Cells

    specialized skin cells that regenerate and repair the epidermis

    Interfollicular Epidermal Stem Cells are specialized cells found in the outer layer of the skin, specifically between hair follicles. These cells play a crucial role in skin regeneration and repair by continuously producing new skin cells to replace those that are shed or damaged.

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    1. Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration Cell Cycle · 2015 · 47 citations
    2. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations
    3. 1323 The effects of 3-OH of kaempferol on interfollicular epidermal stem cell fate Journal of Investigative Dermatology · 2018
    4. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    5. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    6. Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments Histochemistry and Cell Biology · 2010 · 28 citations
    7. Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide Journal of Investigative Dermatology · 2007 · 2 citations
    8. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    9. The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis Anatomical Science International · 2016 · 14 citations
    10. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing Cell Reports · 2018 · 209 citations
    11. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution 2007 · 170 citations
    12. Faculty Opinions recommendation of Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    13. A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004 · 61 citations
    14. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014 · 57 citations
    15. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    16. Epidermal stem cell lineages Advances in stem cells and their niches · 2019 · 1 citations
    17. Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis Development · 2003 · 421 citations
    18. 25 Years of Epidermal Stem Cell Research Journal of Investigative Dermatology · 2012 · 55 citations
    19. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    20. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009 · 503 citations
    21. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017 · 105 citations
    22. Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation PLoS ONE · 2007 · 98 citations
    23. Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures Proceedings of the National Academy of Sciences · 2019 · 67 citations
    24. Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis Nature communications · 2022 · 7 citations
    25. Single cell transcriptomics of human epidermis reveals basal stem cell transition states bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    26. CD4 expression controls epidermal stem cell balance Scientific Reports · 2025 · 1 citations
    27. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    28. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    29. The Role of the Vitamin D Receptor in the Epidermal Stem Cell Response to Wounding Receptors · 2024
    30. Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars Australasian journal of dermatology · 2024