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Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

Phospholipase A2 enzymes play key roles in skin health and disease.

Oral contraceptive use may increase the risk of frontal fibrosing alopecia in women with a specific CYP1B1 gene variant.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

Pregnancy with Cushing's syndrome is rare and risky for both mother and baby, needing early diagnosis and treatment.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

The document covers various male health issues, their causes, treatments, and related conditions.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Antiandrogen treatments combined with oral contraceptives can help manage hair growth and hair loss in women with PCOS.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

New compounds may soon be tested to treat excessive hair growth in women.

Transgender patients need proper skin care, especially when undergoing hormone treatments, to manage issues like acne and hair loss.

The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.

Patients with the same genetic mutation for vitamin D-resistant rickets showed different symptoms but all improved with treatment except for hair loss.

Manage women's cholesterol with diet, exercise, and careful treatment choices, especially during pregnancy, PCOS, and menopause.

Intravenous calcium therapy is a safe and effective treatment for a rare type of rickets.

A postmenopausal woman's excessive hair growth and hair loss were due to a non-cancerous ovarian condition, treated successfully with surgery.

Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.