18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
12 citations
,
December 2022 in “Current Protein and Peptide Science” This review discusses the molecular mechanisms and clinical applications of thymosin β4, highlighting its potential benefits for inflammation, wound healing, tumor metastasis, and other medical conditions but reports no new experimental results.
5 citations
,
December 2021 in “Frontiers in Cell and Developmental Biology” This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.
2 citations
,
December 2023 in “International journal of molecular sciences” This review highlights how wound microbiota, particularly bacteria like Staphylococcus epidermidis and Staphylococcus aureus, significantly influences wound healing dynamics and suggests potential clinical applications through microbiota manipulation.
1 citations
,
January 2012 in “Elsevier eBooks” The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.
March 2026 in “Journal of the European Academy of Dermatology and Venereology” This review suggests that exosomes have potential in dermatology, but their clinical use remains in early development due to challenges in standardization, understanding, and safety.
January 2026 in “Inflammation and Regeneration” This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.
January 2026 in “Chemical Engineering Journal” In this study, researchers developed a programmable system using engineered nanovesicles from hair follicle stem cells to modulate immune responses, which showed promise in precisely controlling inflammation, promoting immune balance, and accelerating wound healing, particularly for infected wounds.
May 2025 in “International Society of Hair Restoration Surgery” This study suggests that exosomes derived from mesenchymal stem cells may promote hair growth and improve skin health by enhancing dermal papilla cell proliferation and modulating inflammation and oxidative stress.
November 2022 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” Platelet-rich fibrin speeds up burn wound healing in rabbits.
6 citations
,
April 2021 in “The Journal of Dermatology” This review highlights cases of hair regrowth in certain patients with cicatricial alopecia, although the mechanism behind this regrowth remains unclear.
July 2026 in “Journal of Applied Pharmaceutical Research” This literature review indicates that skin aging involves complex interactions of both internal and external factors, leading to oxidative stress and cellular damage. The authors report promising results from novel anti-aging interventions, including antioxidants, senolytics, and herbal preparations, for slowing skin aging progression.
December 2023 in “Redox biology” In this study, DMC selectively eliminated senescent cells in old mice, prevented hair loss, improved motor coordination, and reduced senescence-associated secretory factors, suggesting its potential as a senolytic treatment.
June 2018 in “Biomedical Journal of Scientific & Technical Research” This mini review discusses cellular plasticity in cutaneous wound healing and reports no clinical results; the authors aim to enhance regenerative medicine by examining underlying mechanisms.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, mice lacking the Mcpip1 gene in their myeloid cells did not develop SCC-like tumors but instead showed increased melanocyte activity and hair loss, indicating a distinct role for myeloid Mcpip1 in skin cancer development compared to keratinocyte Mcpip1.
March 2026 in “Preprints.org” This study investigated the secretome of adipose mesenchymal stem cells and fibroblasts used in skin care products, finding 16 therapeutic pathways involving numerous signaling mechanisms, which may offer skin benefits through anti-inflammatory and regenerative effects.
October 2022 in “Faculty of 1000 Research Ltd” This review discusses the roles of various growth factors and cytokines in skin regeneration, highlighting their potential for future therapeutic development, and reports no new experimental findings.
252 citations
,
April 2009 in “Seminars in Cell & Developmental Biology” This review discusses the complex role of the immune system in tissue repair and regeneration, highlighting its positive and negative influences but reports no new clinical findings.
127 citations
,
December 2005 in “Experimental Dermatology” This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.
110 citations
,
February 2024 in “Journal of Chemical Information and Modeling” This study describes the PandaOmics platform, which uses AI and bioinformatics to identify new therapeutic targets and biomarkers for various diseases, demonstrating validation in laboratory and animal studies.
106 citations
,
August 2021 in “Pharmaceuticals” This review discusses the role of extracellular vesicles in wound healing and explores their potential applications in skin repair and treatment of dermal diseases, reporting no new clinical findings.
87 citations
,
September 2014 in “International Journal of Molecular Sciences” This study found that the transcription factor FOXO1 plays a crucial role in wound healing by protecting keratinocytes from oxidative stress and regulating TGF-β expression.
80 citations
,
April 2006 in “Clinical Interventions in Aging” This review discusses factors affecting hair aging and the current pharmacological treatments for androgenetic alopecia, mentioning topical minoxidil and oral finasteride, but does not present new clinical findings.
77 citations
,
July 2020 in “Journal of the European Academy of Dermatology and Venereology” This review examines the skin exposome, including solar exposure, air pollution, hormones, nutrition, and psychological factors, but reports no new clinical results.
76 citations
,
June 2015 in “Journal of biomedical science” This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.
65 citations
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February 2017 in “Pflügers Archiv - European Journal of Physiology” This review examines the roles of macrophages and Langerhans cells in skin homeostasis and suggests that understanding these functions can aid in developing therapies for skin and hair regeneration, but it reports no new research findings.
55 citations
,
April 2018 in “Advanced Healthcare Materials” This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.
50 citations
,
February 2022 in “Nanomaterials” This review discusses the mechanisms involved in wound healing and explores the potential of nanomaterials as a promising approach to managing chronic wounds, but reports no new clinical findings.
49 citations
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August 2007 in “Dermatologic surgery” This review discusses newer therapeutic techniques for treating postacne scarring, highlighting their effectiveness for particular grades of scars, and reports no new clinical results.
44 citations
,
June 2024 in “Regenerative Therapy” This review discusses adverse events potentially linked to platelet-rich plasma therapy, highlighting the need for more high-quality evidence to understand its safety profile and associated risks.