Loss of Myeloid Mcpip1 Suppresses Hair Growth and Development of Epidermal Papilloma of the Skin

    November 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Weronika Szukała, Krzysztof Goryca, Izabela Rumieńczyk, Michał Mikula, Leopold Eckhart, J. Kozieł, Jolanta Jura, Agata Lichawska-Cieślar
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    Studysummary In this study, mice lacking the Mcpip1 gene in their myeloid cells did not develop SCC-like tumors but instead showed increased melanocyte activity and hair loss, indicating a distinct role for myeloid Mcpip1 in skin cancer development compared to keratinocyte Mcpip1. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigates the role of myeloid Mcpip1 (Mcpip1-MKO) in skin carcinogenesis using a DMBA/TPA-induced model. Unlike control mice that developed numerous papillomas, Mcpip1-MKO mice did not develop SCC-like tumors but instead developed multiple pigmented nevi and experienced complete hair loss in treated areas. Histological analysis revealed melanin accumulation around hair follicle remnants and immune cell infiltration, primarily macrophages. RNA-sequencing indicated upregulated inflammation-related processes and downregulated epithelial cell proliferation and Wnt-signaling pathways in Mcpip1-MKO mice. The findings highlight distinct roles for keratinocyte- and myeloid-Mcpip1 in skin carcinogenesis, contrasting with previous observations in Mcpip1-EKO mice.
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