Loss of Myeloid Mcpip1 Suppresses Hair Growth and Development of Epidermal Papilloma of the Skin

    November 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Weronika Szukała, Krzysztof Goryca, Izabela Rumieńczyk, Michał Mikula, Leopold Eckhart, J. Kozieł, Jolanta Jura, Agata Lichawska-Cieślar
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    TLDR Removing MCPIP1 from myeloid cells in mice leads to hair loss and prevents skin tumors but causes pigmented spots.
    The study investigates the role of myeloid Mcpip1 (Mcpip1-MKO) in skin carcinogenesis using a DMBA/TPA-induced model. Unlike control mice that developed numerous papillomas, Mcpip1-MKO mice did not develop SCC-like tumors but instead developed multiple pigmented nevi and experienced complete hair loss in treated areas. Histological analysis revealed melanin accumulation around hair follicle remnants and immune cell infiltration, primarily macrophages. RNA-sequencing indicated upregulated inflammation-related processes and downregulated epithelial cell proliferation and Wnt-signaling pathways in Mcpip1-MKO mice. The findings highlight distinct roles for keratinocyte- and myeloid-Mcpip1 in skin carcinogenesis, contrasting with previous observations in Mcpip1-EKO mice.
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