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    Glossary Indian Hedgehog

    signaling protein crucial for hair follicle development and cycling

    Indian Hedgehog (Ihh) is a signaling protein that plays a crucial role in the regulation of embryonic development, including the formation of hair follicles. It is part of the Hedgehog signaling pathway, which is essential for cell differentiation and tissue patterning. In the context of hair biology, Ihh influences the growth and cycling of hair follicles, and disruptions in this pathway can lead to conditions like alopecia.

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    1. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development · 2004 · 99 citations
    2. Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression Cell Reports · 2013 · 15 citations
    3. The effects of sonic, desert and Indian hedgehog signalling in skin 2003
    4. Developmental signals in skin morphogenesis Experimental Dermatology · 2004
    5. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005 · 113 citations
    6. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    7. Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation FEBS Journal · 2021 · 23 citations
    8. Molecular Signaling and Nutritional Regulation in the Context of Poultry Feather Growth and Regeneration Frontiers in Physiology · 2020 · 4 citations
    9. Abstract CN06-04: The hedgehog signaling pathway in cancer. Molecular Cancer Therapeutics · 2011
    10. MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives Frontiers in Cell and Developmental Biology · 2026
    11. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    12. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    13. Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms ˜The œAmerican journal of pathology · 2011 · 68 citations
    14. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    15. Effect of Sonic Hedgehog on the Regeneration of Epidermal Texture Patterns Biomedicines · 2022 · 6 citations
    16. Lgr5 Stem Cells and Potential Treatments for Hair Loss Theoretical and Natural Science · 2026
    17. Efecto Inmunohistoquímico de la Vitamina E y el Ácido Valproico en el Desarrollo de Epidermis y Folículos Pilosos International Journal of Morphology · 2025
    18. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog Journal of Clinical Investigation · 1999 · 231 citations
    19. Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner International Journal of Dermatology and Clinical Research · 2019
    20. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    21. Hedgehog Signaling, Keratin 6 Induction, and Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008 · 33 citations
    22. Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling Stem Cells · 2019 · 20 citations
    23. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    24. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    25. Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma Journal of Oncology · 2022 · 5 citations
    26. Hedgehog Pathway Inhibitors against Tumor Microenvironment Cells · 2021 · 21 citations
    27. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    28. Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors International Journal of Molecular Sciences · 2026
    29. The Prevalence of Scopulariopsis sp. and Penicillium sp. in African Pygmy Hedgehogs (Atelerix albiventris) Skins in a Farm in Bogor District of Indonesia Media Kedokteran Hewan · 2025
    30. Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans American Journal Of Pathology · 2006 · 35 citations