TLDR Two new compounds were found to effectively reduce hair growth in mice.
In the study from 2010, researchers synthesized a series of aminomethylpyrazoles and tested them for their ability to inhibit the Smoothened (Smo) pathway, which is involved in hair growth. Two compounds, 10k and 10l, demonstrated potent Smo antagonism and were effective in suppressing hair growth in the C3H/HeN mouse model. Compound 10l, which was more selective, also showed a low risk of causing photo-irritation as it tested negative in the 3T3 NRU assay. Although 10l was slightly less effective than the reference compound eflornithine, it was still efficacious in reducing hair growth in mice.
113 citations,
September 2005 in “Journal of Investigative Dermatology” Applying a special compound can promote hair growth without harmful side effects.
24 citations,
April 2005 in “The Journal of Dermatology” Putting ketoconazole on the skin can help mice grow hair.
105 citations,
April 2014 in “Trends in Pharmacological Sciences” Targeting the Smoothened receptor shows promise for treating certain cancers.
3 citations,
September 2019 in “Clinical and experimental dermatology” Basal cell carcinomas may differentiate similarly to hair follicles and could be influenced by hair cycle-related treatments.
June 2019 in “International journal of dermatology and venereology” The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.
21 citations,
November 2021 in “Cells” Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.
4 citations,
December 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.
