December 2024 in “Frontiers in Neurology” In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.
September 2024 in “Egyptian Journal of Dermatology and Venerology” In this interventional study on female-pattern hair loss, researchers found that fractional CO2 laser therapy alone improved hair growth, as evidenced by increased hair count, thickness, density, and patient satisfaction compared to saline controls. However, the precise mechanisms behind these effects require further investigation.
July 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences” This pilot study evaluated a hair growth serum on 51 individuals aged 21 to 45, observing that it effectively reduced hair fall, promoted hair growth, and increased hair thickness and density without side effects, with high user satisfaction in Mumbai, India.
December 2023 in “Gugje bogeon mi-yong haghoeji” In this study, researchers observed that aroma oil-enhanced scalp scaling significantly improved scalp conditions over 8 weeks, marked by increased water and oil content, reduced keratin and surface value, and higher satisfaction in hair-related outcomes compared to the control group.
May 2023 in “Journal of Applied Cosmetology” In this randomized controlled trial, researchers found that participants with androgenic alopecia taking an Annurca apple extract supplement showed significant increases in hair density and weight and reduced hair loss compared to a placebo, with good skin and gastrointestinal tolerability over 180 days.
In this study, minoxidil 2% produced satisfactory esthetical results in about 30% of patients, but placebo-treated subjects experienced increased hair counts without a cosmetic benefit, possibly due to seasonal variations and hair classification issues.
June 2021 in “Egyptian Journal of Dermatology and Venereology” This study found that psoriasis, acne, and androgenetic alopecia are associated with an atherogenic lipid profile, suggesting an increased risk of atherosclerosis and cardiovascular disease, especially among psoriasis patients.
January 2021 in “Menoufia Medical Journal” This study found that patients with early-onset androgenetic alopecia had significantly higher levels of fasting blood sugar, triglycerides, and cholesterol, suggesting an increased risk of developing coronary artery disease.
December 2013 in “Tehran University Medical Journal TUMS Publications” In this study, no significant relationship was found between androgenetic alopecia and hyperlipidemia, but higher levels of cholesterol, LDL, and triglycerides in AGA patients may suggest an increased risk of coronary heart disease.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this randomized control trial, the researchers found that intralesional triamcinolone acetonide led to higher hair density increases than Vitamin D supplementation in alopecia areata patients, although potential hair regrowth was also noted with Vitamin D in those with deficient levels.
This study reviewed the efficacy of hair intradermotherapy for treating androgenetic alopecia, finding that the technique, whether used alone or with other interventions, can increase hair density, reduce hair loss, and improve patient self-esteem, although professional supervision is recommended to minimize adverse effects.
57 citations
,
August 2003 in “British Journal of Dermatology” This study found that daily use of 1% pyrithione zinc shampoo modestly improved hair growth over 26 weeks, although these effects were less than those of 5% minoxidil.
3 citations
,
July 2016 in “International Journal of Dermatology” This case report describes an Asian girl with short anagen syndrome who experienced improved hair density after using minoxidil.
February 2026 in “Journal of the Korean Society of Cosmetology” This study found that applying a red clover-chamomile complex extract ampoule for 4 weeks significantly improved hair density and shaft thickness at the hairline in participants with self-perceived decreased density.
March 2025 in “International Journal For Multidisciplinary Research” This study reports that Murraya koenigii (curry leaf) extract, rich in bioactive compounds, shows potential in promoting hair growth and improving scalp health through increased follicle density, reduced hair loss, and antimicrobial effects, with clinical trials supporting these benefits.
In this study, researchers developed and tested an herbal hair serum containing natural ingredients like banana flower extract and orange oil, which was stable and pH-balanced, with preliminary user feedback suggesting improved hair texture, reduced hair fall, and increased hair density.
This chapter reviews the causes, prevalence, and prognosis of androgenetic alopecia and discusses treatments like topical minoxidil and systemic finasteride to stop hair loss and potentially increase hair density.
May 2026 in “Malaysian Journal of Medicine and Health Sciences” This study found that in a testosterone-induced androgenetic alopecia mouse model, the combination of PRP-derived small extracellular vesicles and 5% minoxidil significantly improved hair follicle density and the anagen-to-telogen ratio compared to minoxidil alone, suggesting a synergistic effect that enhances hair growth.
October 2025 in “Advanced Materials” In this study, researchers developed ionizable coenzyme Q10-engineered lipid/fiber microplexes that restored mitochondrial-ribosomal function and enhanced mRNA translation in senescent cells, leading to increased hair follicle density and bone formation in mouse models compared to conventional lipid nanoparticles.
This study found that applying amaranthus extract cream to the scalp significantly improved terminal hair density, anagen hair count, and pilary index in men with male pattern hair loss, suggesting it may be a safe and effective supportive therapy.
June 2025 in “Journal of the Pakistan Medical Association” In this study, researchers explored the use of a 2-deoxy-D-ribose sodium alginate hydrogel on mice with androgenic alopecia and found it resulted in similar hair regrowth to minoxidil, highlighting increased hair follicle density and angiogenesis.
December 2023 in “Journal of Food Science and Nutrition” In this animal study, rosehip seed oil applied to the skin of mice promoted hair regrowth by accelerating hair follicles' transition from resting to growth phases and increased hair follicle density, bulb size, and skin thickness, suggesting potential as a treatment for hair loss.
October 2023 in “FASEB bioAdvances” This study investigated the effects of Akkermansia muciniphila on testosterone-induced hair growth inhibition in mice, finding that both live and pasteurized forms significantly encouraged hair growth and increased hair follicle size and growth factor levels compared to testosterone treatment alone.
61 citations
,
April 2012 in “British Journal of Dermatology” This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.
51 citations
,
November 1988 in “The Journal of Clinical Endocrinology & Metabolism” This study found that serum 3 alpha-Adiol-G levels in men are significantly associated with chest hair density and acne, indicating its role in reflecting androgen activity in peripheral tissues.
33 citations
,
May 2017 in “Journal of Clinical Oncology” This phase I study reported that ETC-159, targeting Wnt signalling, showed tolerable safety profiles at doses that inhibit its pathway, though bone turnover markers increased, warranting early and regular monitoring. No tumor responses were observed, but two patients achieved stable disease for several cycles.
30 citations
,
December 2017 in “Clinical, Cosmetic and Investigational Dermatology” This study found significant differences in hair density, non-vellus hair diameter, and percentage of miniaturized hair between normal women and those with female pattern hair loss, particularly in the midscalp and parietal areas.
16 citations
,
January 2021 in “BMC Genomics” This study found that high wool-producing Wan Strain Angora rabbits had higher hair follicle density and identified potential regulatory long noncoding RNAs that may influence this trait.
15 citations
,
September 2016 in “Trauma Monthly” This study found that topical Linum usitatissimum gel significantly enhanced wound healing and tissue regeneration in rat models, with increased collagen synthesis and vascularization compared to controls.
8 citations
,
April 2023 in “Dermatology Practical & Conceptual” This study reported that higher monocyte lymphocyte ratio, monocyte high-density lipoprotein cholesterol ratio, and platelet lymphocyte ratio were associated with increased risk of developing alopecia areata, suggesting their potential as diagnostic markers.