Correlation of Serum 3α-Androstanediol Glucuronide with Acne and Chest Hair Density in Men

The study examined 44 male medical students to explore the relationship between serum 3 alpha-androstanediol glucuronide (3 alpha-Adiol-G) and physical traits like chest hair density and acne. It found significant correlations between higher serum 3 alpha-Adiol-G levels and increased chest hairiness (P = 0.0034), acne (P = 0.0005), and a combined score of both (P = 0.0018). These findings suggested that serum 3 alpha-Adiol-G levels might reflect androgen action in peripheral tissues, as they were also strongly correlated with bioavailable testosterone (P = 0.0005), but not with precursor androgen levels.