Characterization of Lipid Profile in Psoriasis, Acne Vulgaris, and Androgenetic Alopecia: A Case-Control Study

June 2021 in “ Egyptian Journal of Dermatology and Venereology ”

Shereen Adel, Galal A. Nassef, Mostafa Ezzat, Marwa M. Khalaf, Talal Abd-ElRaheem

androgenetic alopecia psoriasis acne vulgaris low-density lipoprotein high-density lipoprotein cholesterol triglycerides dyslipidemia atherogenic lipid profile atherosclerosis cardiovascular disease body mass index AGA LDL HDL BMI

TLDR Psoriasis, acne, and hair loss are linked to unhealthy cholesterol levels, increasing heart disease risk.

The study investigated the lipid profiles of 25 patients each with psoriasis, acne vulgaris, and androgenetic alopecia (AGA), compared to 25 healthy controls, totaling 100 participants. It found that patients with these conditions had significantly higher low-density lipoprotein (LDL) and lower high-density lipoprotein (HDL) levels compared to controls, indicating a dyslipidemic state. This was most pronounced in psoriasis patients, who also had elevated cholesterol and triglyceride levels. The severity of psoriasis and acne was negatively correlated with HDL levels, while AGA severity was positively correlated with BMI. The study concluded that these conditions are associated with an atherogenic lipid profile, particularly in psoriasis, suggesting a potential risk for atherosclerosis and cardiovascular disease, independent of traditional atherosclerotic risk factors except obesity.

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