Characterization of Lipid Profile in Psoriasis, Acne Vulgaris, and Androgenetic Alopecia: A Case-Control Study

June 2021 in “ Egyptian Journal of Dermatology and Venereology ”

Shereen Adel, Galal A. Nassef, Mostafa Ezzat, Marwa M. Khalaf, Talal Abd-ElRaheem

androgenetic alopecia psoriasis acne vulgaris low-density lipoprotein high-density lipoprotein cholesterol triglycerides dyslipidemia atherogenic lipid profile atherosclerosis cardiovascular disease body mass index AGA LDL HDL BMI

TLDR Psoriasis, acne, and hair loss are linked to unhealthy cholesterol levels, increasing heart disease risk.

The study investigated the lipid profiles of 25 patients each with psoriasis, acne vulgaris, and androgenetic alopecia (AGA), compared to 25 healthy controls, totaling 100 participants. It found that patients with these conditions had significantly higher low-density lipoprotein (LDL) and lower high-density lipoprotein (HDL) levels compared to controls, indicating a dyslipidemic state. This was most pronounced in psoriasis patients, who also had elevated cholesterol and triglyceride levels. The severity of psoriasis and acne was negatively correlated with HDL levels, while AGA severity was positively correlated with BMI. The study concluded that these conditions are associated with an atherogenic lipid profile, particularly in psoriasis, suggesting a potential risk for atherosclerosis and cardiovascular disease, independent of traditional atherosclerotic risk factors except obesity.

View this study on ejdv.eg.net →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 month ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community "DHT Itch" and onset Seborrheic Dermatitis

in Research/Science 76 upvotes 1 year ago

The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

community What an amazing time to be alive

in Finasteride/Dutasteride 184 upvotes 1 year ago

The post discusses a user's experience with hair loss treatments, specifically topical finasteride, minoxidil, and micro-needling, and their plan to switch to oral versions and add Dutasteride. The conversation includes various responses, with some users sharing their own experiences and side effects, and others expressing desire for a more permanent hair loss solution.