Characterization of Lipid Profile in Psoriasis, Acne Vulgaris, and Androgenetic Alopecia: A Case-Control Study

The study investigated the lipid profiles of 25 patients each with psoriasis, acne vulgaris, and androgenetic alopecia (AGA), compared to 25 healthy controls, totaling 100 participants. It found that patients with these conditions had significantly higher low-density lipoprotein (LDL) and lower high-density lipoprotein (HDL) levels compared to controls, indicating a dyslipidemic state. This was most pronounced in psoriasis patients, who also had elevated cholesterol and triglyceride levels. The severity of psoriasis and acne was negatively correlated with HDL levels, while AGA severity was positively correlated with BMI. The study concluded that these conditions are associated with an atherogenic lipid profile, particularly in psoriasis, suggesting a potential risk for atherosclerosis and cardiovascular disease, independent of traditional atherosclerotic risk factors except obesity.