Comparison of Hair Follicle Density and Anagen:Telogen Ratio Between Topical Minoxidil Alone and Its Combination With Platelet-Rich Plasma Exosomes in a Mouse Model of Androgenetic Alopecia

    May 2026 in “ Malaysian Journal of Medicine and Health Sciences ”
    Pristia Widya Monica, Harijono Kariosentono, Indah JuliNTO … Suci Widhiati
    Studysummary This study found that in a testosterone-induced androgenetic alopecia mouse model, the combination of PRP-derived small extracellular vesicles and 5% minoxidil significantly improved hair follicle density and the anagen-to-telogen ratio compared to minoxidil alone, suggesting a synergistic effect that enhances hair growth.
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    Research cited in this study 10

    1. Advancements in Bioactive Compounds and Therapeutic Agents for Alopecia: Trends and Future Perspectives Cosmetics · 2025
    2. Platelet-Rich Plasma: Molecular Mechanisms, Actions, and Clinical Applications in the Human Body International Journal of Molecular Sciences · 2025
    3. The Evolution of Three Generations of Platelet Concentrates Products: A Leap from Classical Formulations to the Era of Extracellular Vesicles Frontiers in Bioengineering and Biotechnology · 2025
    4. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway Stem Cell Research & Therapy · 2025
    5. Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway Regenerative Therapy · 2025
    6. Exosomes Derived Stem Cells as a Modern Therapeutic Approach for Skin Rejuvenation and Hair Regrowth Regenerative Therapy · 2024
    7. Combination Therapy with Platelet-Rich Plasma and Minoxidil Leads to Better Clinical Results Than Monotherapy in Men with Androgenetic Alopecia International Journal of Trichology · 2022
    8. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    9. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    10. Animal Models of Androgen-Dependent Disorders of the Pilosebaceous Apparatus Archives of dermatological research · 1989