Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases

    October 2025 in “ Advanced Materials
    Shifeng Ling, Yixiang Zhang, Yanyang Chen, Wei He, Tianqi Wu, Juan Wang, Yingying Wei, Min Lu, Weili Zhao, Qingfeng Li, Yawei Du, Wenguo Cui
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    Studysummary In this study, researchers developed ionizable coenzyme Q10-engineered lipid/fiber microplexes that restored mitochondrial-ribosomal function and enhanced mRNA translation in senescent cells, leading to increased hair follicle density and bone formation in mouse models compared to conventional lipid nanoparticles.
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