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GlossaryIn Vitro Skin Absorption (in vitro skin penetration)

study of substance penetration through skin in lab settings

In Vitro Skin Absorption refers to the process of studying how substances penetrate the skin using laboratory techniques outside of a living organism. This method involves applying a substance to a skin sample, often from human or animal sources, and measuring how much of the substance passes through the skin layers. It is commonly used in research and product development to assess the safety and efficacy of topical medications, cosmetics, and other skin-applied products.

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Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies

research Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies

35 citations, January 2018 in “Skin pharmacology and physiology”

Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.

Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

research Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

82 citations, January 2002 in “Journal of drug targeting”

Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.

Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies

research Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies

28 citations, March 2014 in “International Journal of Nanomedicine”

New lipid nanoparticles show promise for delivering hair loss treatments but need improvement for better skin penetration.

research Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment

48 citations, December 2013 in “Drug Delivery and Translational Research”

Niosomes improve minoxidil skin penetration for hair loss treatment.

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

55 citations, June 2009 in “Journal of Pharmaceutical Sciences”

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

research Influence of Chemical Permeation Enhancers on the In Vitro Skin Permeation of Minoxidil Through Excised Rat Skin: A Mechanistic Study

January 2018 in “Iranian Journal of Pharmaceutical Sciences”

Urea, eucalyptus oil, and menthol improve minoxidil skin absorption.

Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations, June 2017 in “Journal of pharmaceutical sciences”

Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.

research In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel With Reduced Runoff for Eyebrow Hair Growth

March 2023 in “Gels”

The new minoxidil gel reduces runoff and improves eyebrow hair growth.

research Ion Pairs of Risedronate for Transdermal Delivery and Enhanced Permeation Rate on Hairless Mouse Skin

34 citations, July 2011 in “International journal of pharmaceutics”

Ion-paired risedronate significantly increases skin penetration without irritation compared to risedronate alone.

research Preparation and In Vivo Evaluation of Lecithin-Based Microparticles for Topical Delivery of Minoxidil

12 citations, August 2017 in “Archives of Pharmacal Research”

Lecithin-based microparticles can deliver minoxidil for hair growth effectively with less skin irritation.

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

128 citations, July 2009 in “International Journal of Pharmaceutics”

PEVs improve minoxidil skin penetration, increasing hair growth.

Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction

research Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction

21 citations, April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.

research The Use of Biodegradable Microneedle Patches to Increase Penetration of Topical Steroid for Prurigo Nodularis

5 citations, January 2018 in “PubMed”

Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.

research The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and Across the Skin

1 citations, February 2024 in “Pharmaceutics”

Nanovesicles improve drug delivery through the skin, offering better treatment outcomes and fewer side effects.

research Nanoethosomes for Dermal Delivery of Lidocaine

30 citations, November 2015 in “Advanced Pharmaceutical Bulletin”

Nanoethosomes can improve the skin penetration of Lidocaine for topical use.

research Factors Influencing Hydrocortisone Permeation Into Human Hair Follicles: Use of the Skin Sandwich System

16 citations, March 2008 in “International journal of pharmaceutics”

Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.

research Drug Permeation Through Hair Follicles: Importance and Potential

1 citations, January 2017 in “Springer eBooks”

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

research Formulation and Characterization of Transethosomes for Enhanced Transdermal Delivery of Propranolol Hydrochloride

11 citations, January 2020 in “Micro and Nanosystems”

The new gel improves skin delivery of a drug, potentially reducing dose frequency and side effects.

research Hair Growth Promoting Effect of Bioactive Extract from Deer Antler Velvet-Loaded Niosomes and Microspicules Serum

14 citations, February 2021 in “International Journal of Pharmaceutics”

Deer antler velvet serum helps hair grow and is safe for skin.

research Polymeric Nanoparticles-Embedded Organogel for Roxithromycin Delivery to Hair Follicles

47 citations, July 2014 in “European Journal of Pharmaceutics and Biopharmaceutics”

Scientists created a gel with nanoparticles to deliver medicine to hair follicles effectively.

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

84 citations, July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.

research In Vitro Skin Permeation of Monoolein Nanoparticles Containing Hydroxypropyl β-Cyclodextrin/Minoxidil Complex

39 citations, April 2010 in “International Journal of Pharmaceutics”

Nanoparticles improve minoxidil skin permeation, but more research needed for effective hair growth.

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

268 citations, April 2009 in “International Journal of Pharmaceutics”

Niosomes improve minoxidil skin delivery for hair loss treatment.

research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles

32 citations, June 2017 in “Journal of Pharmaceutical Sciences”

Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.

research Testosterone Metabolism in Human Skin Cells In Vitro and Its Interaction with Estradiol and Dutasteride

21 citations, January 2003 in “Skin pharmacology and physiology”

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

research Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations, June 2014 in “Journal of Pharmaceutical Sciences”

Finasteride cream helps hair growth with less side effects.

research Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

12 citations, December 2017 in “Food and chemical toxicology”

Permanent hair dye mixtures can irritate and damage the skin.

research In Vivo Penetration of Bare and Lipid-Coated Silica Nanoparticles Across the Human Stratum Corneum

16 citations, August 2014 in “Colloids and surfaces. B, Biointerfaces”

Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.

Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles

research Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles

December 2023 in “Biological & pharmaceutical bulletin”

IPM enhances skin penetration of hydrophilic drugs.

research The Effect of Various Vehicles on the In Vitro Skin Permeability of Minoxidil

October 2022 in “Journal of Kermanshah University of Medical Sciences”

Different substances can affect how well the skin absorbs minoxidil, a hair loss drug. Caprylic acid helps the skin absorb it the best, followed by propylene glycol and water.