Influence of Chemical Permeation Enhancers on the In Vitro Skin Permeation of Minoxidil Through Excised Rat Skin: A Mechanistic Study

January 2018 in “ Iranian Journal of Pharmaceutical Sciences ”

Eskandar Mmoghimipour, Anayatollah Salimi, Ali Talebpour Jahromi

minoxidil androgenetic alopecia chemical permeation enhancers urea eucalyptus oil menthol skin permeability lipid fluidization stratum corneum Rogaine

TLDR Urea, eucalyptus oil, and menthol improve minoxidil skin absorption.

The study investigated the effect of chemical permeation enhancers on the skin permeability of minoxidil using excised rat skin. Minoxidil, a treatment for androgenetic alopecia, typically shows low skin penetration. The research used urea, eucalyptus oil, and menthol as enhancers, finding that they increased the flux and diffusion coefficient of minoxidil by 1.86, 2.16, and 1.75 times, and 3.25, 1.34, and 2.16 folds, respectively, compared to hydrated skin. The study concluded that these enhancers improved minoxidil permeability by causing lipid fluidization, extraction, disruption of lipid structure, and irreversible protein denaturation in the skin's stratum corneum layer.

View this study on ijps.ir →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Fats on your Head to Stop Hair Loss?

in Research/Science 138 upvotes 9 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community 15 months total on Dut/Min/RU and microneedling 1mm every other week

in Progress Pictures 1746 upvotes 2 months ago

The user reported significant hair improvement over 15 months using dutasteride, minoxidil (oral and topical), RU58841, ketoconazole, and microneedling. They are considering a hair transplant in 4-6 months.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Actor Paul Mescal, 26, has a receding hairline. I thought it was pretty cool to see a younger actor being successful, despite dealing with hair loss. He just got nominated for an Oscar.

in Chat 353 upvotes 1 year ago

Actor Paul Mescal, who has a receding hairline, and how it affects his success in the entertainment industry. People discussed how styling can help disguise hair loss, and that hair loss doesn't necessarily mean one's appearance is immediately ruined. Treatments such as Minoxidil and Finasteride were mentioned to combat hair loss.

community Are most men bald because they haven’t tried any treatment or are they bald in spite of it?

in Shaved/buzzed 307 upvotes 7 months ago

Some men are bald because they are unaware of hair loss treatments like Minoxidil (Min) and Finasteride (Fin), while others choose not to use them due to potential side effects, cost, or personal preference. Treatments like Min and Fin are discussed, with varying results and opinions on their effectiveness and side effects.

Similar Research

5 / 1000+ results

research Effect of Various Herbal and Chemical Enhancers on Skin Permeability to Cetirizine: A Study of Changes in Rat Skin Cells

June 2024 in “Majallah-i dānishgāh-i ̒ulum-i pizishkī-i Kirmān.”

Eucalyptus and Tween 80 most effectively increase cetirizine skin absorption.

research The Effect of Various Vehicles on the In Vitro Skin Permeability of Minoxidil

October 2022 in “Journal of Kermanshah University of Medical Sciences”

Different substances can affect how well the skin absorbs minoxidil, a hair loss drug. Caprylic acid helps the skin absorb it the best, followed by propylene glycol and water.

research Microneedle Arrays Combined With Nanomedicine Approaches for Transdermal Delivery of Therapeutics

42 citations, January 2021 in “Journal of Clinical Medicine”

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

research The Novel Excipient, Dodecyl-2-N, N-Dimethylaminopropionate Hydrochloride (DDAIP-HCl) Improves the Flux of Minoxidil in Human Skin

2 citations, January 2012 in “Hair therapy & transplantation”

DDAIP-HCl significantly increases minoxidil absorption into the skin.

research Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

22 citations, March 2020 in “Cosmetics”

Nanotechnology improves minoxidil treatment for hair loss.