TLDR Eucalyptus and Tween 80 most effectively increase cetirizine skin absorption.
This study examined the impact of various enhancers on the skin permeability of cetirizine, an antihistamine used for androgenic alopecia treatment. Enhancers such as eucalyptus, menthol, Tween 80, propylene glycol, and oleic acid were tested. Eucalyptus and Tween 80 were the most effective in increasing skin permeability, while propylene glycol was the least effective. The study identified mechanisms like lipid liquefaction, lipid structure destruction, and keratin denaturation as reasons for increased permeability. These results suggest that enhancing cetirizine's topical formulation could improve its absorption.
October 2022 in “Journal of Kermanshah University of Medical Sciences” Different substances can affect how well the skin absorbs minoxidil, a hair loss drug. Caprylic acid helps the skin absorb it the best, followed by propylene glycol and water.
August 2022 in “Journal of Cosmetic Dermatology” 1% topical cetirizine may help treat hair loss but is less effective than minoxidil.
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September 2023 in “Journal of Cosmetic Dermatology” Topical cetirizine may help increase hair length in male pattern baldness and could be an alternative to minoxidil with fewer side effects.
July 2023 in “Research Square (Research Square)” Using Cetirizine 1% cream daily can significantly improve hair growth and thickness in men with hair loss, and it's safe to use.
1 citations,
July 2023 in “Cureus” Some treatments for hereditary hair loss are effective but vary in results and side effects; new therapies show promise but need more research.
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October 2021 in “Exploration of targeted anti-tumor therapy” Breast cancer hormone therapy can cause hair loss, which can be treated with daily applications of specific topical solutions like minoxidil and hydrocortisone butyrate.
March 2024 in “International journal of pharmaceutics. X” Spanlastic-laden nanogel could be a better way to deliver hair growth medication through the skin for treating hair loss.
