TLDR Eucalyptus and Tween 80 most effectively increase cetirizine skin absorption.
This study investigated the effect of various enhancers on the skin permeability of cetirizine, a hydrophilic antihistamine used in androgenic alopecia treatment. Enhancers such as eucalyptus, menthol, Tween 80, propylene glycol, and oleic acid were tested on rat skin. The results indicated that all enhancers increased cetirizine's permeability compared to water, with mechanisms involving lipid liquefaction, lipid structure destruction, and keratin denaturation. Eucalyptus and Tween 80 were the most effective enhancers, while propylene glycol was the least effective after 2- and 1-hour pre-contact, respectively.
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October 2021 in “Exploration of targeted anti-tumor therapy” Breast cancer hormone therapy can cause hair loss, which can be treated with daily applications of specific topical solutions like minoxidil and hydrocortisone butyrate.
March 2024 in “International journal of pharmaceutics. X” Spanlastic-laden nanogel could be a better way to deliver hair growth medication through the skin for treating hair loss.
