Altered Skin Permeation of Finasteride Using Clove Oil, Urea, and Lyophilized Powder of Grape Seed Extract

January 2022 in “ Advanced Pharmaceutical Bulletin ”

Anayatollah Salimi, Hamid R Soleymani, Saeed Mohammad Soleymani

finasteride clove oil urea lyophilized powder of grape seed extract LPGSE skin permeability hair loss acne Propecia grape seed extract

TLDR Clove oil and grape seed extract increase finasteride skin absorption, while urea decreases it.

The study investigated the effect of clove oil, urea, and lyophilized powder of grape seed extract (LPGSE) on the skin permeability of finasteride, a drug used to treat hair loss and acne. The skin was pretreated with these enhancers for 2 and 4 hours. Results showed that clove oil and LPGSE increased finasteride permeability, with clove oil (4 hours) showing the highest permeation rate. Conversely, urea reduced finasteride penetration with increased pretreatment time due to reversible effects. The study concludes that clove oil and LPGSE are effective penetration enhancers for finasteride, while urea is less effective.

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Research cited in this study

5 / 5 results

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research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

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84 citations, July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.

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1 / 1 results

research Altered Skin Permeation of Finasteride Using Clove Oil, Urea, and Lyophilized Powder of Grape Seed Extract

January 2022 in “Advanced Pharmaceutical Bulletin”

Clove oil and grape seed extract increase finasteride skin absorption, while urea decreases it.

Altered Skin Permeation of Finasteride Using Clove Oil, Urea, and Lyophilized Powder of Grape Seed Extract

Research cited in this study

research A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women

research Clinical Biochemistry of Dihydrotestosterone

research Finasteride and Sexual Side Effects

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

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research Altered Skin Permeation of Finasteride Using Clove Oil, Urea, and Lyophilized Powder of Grape Seed Extract