The Use of Biodegradable Microneedle Patches to Increase Penetration of Topical Steroid for Prurigo Nodularis

January 2018 in “ PubMed ”

Jung U Shin, Jung Dong Kim, Hong Kee Kim, Hong Kyu Kang, Chulmin Joo, Ju Hee Lee, Do Hyeon Jeong, Seungri Song, Howard Chu, Jungsoo Lee, Hemin Lee, Kwang Hoon Lee

biodegradable microneedle patches topical steroids prurigo nodularis mometasone furoate in vitro test clinical study lesion reduction pruritus scores refractory skin diseases MN patches steroid cream skin lesions itchiness

TLDR Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.

The study investigated the use of biodegradable microneedle (MN) patches to enhance the penetration of topical steroids in treating prurigo nodularis. It included an in vitro test and a clinical study with 24 East Asian patients. The in vitro results showed increased steroid penetration with MN patches. Clinically, patients applied mometasone furoate cream twice daily, with MN patches weekly on one side of the body. After four weeks, the MN-treated side showed significantly greater lesion reduction and lower pruritus scores. The study concluded that MN patches could improve treatment for refractory skin diseases like prurigo nodularis.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

Morphometric Analysis of the Human Scalp Hair Follicle: Practical Implications for the Hair Transplant Surgeon and Hair Regeneration Studies

research Morphometric Analysis of the Human Scalp Hair Follicle: Practical Implications for the Hair Transplant Surgeon and Hair Regeneration Studies

51 citations, November 2010 in “Dermatologic Surgery”

The research provides specific measurements for hair follicles that can improve hair transplant and regeneration techniques.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model

69 citations, February 2008 in “The American journal of pathology”

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

research Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation

56 citations, January 2007 in “Pharmaceutical Development and Technology”

Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.

research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations, April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.

Related Research

1 / 1 results

research The Use of Biodegradable Microneedle Patches to Increase Penetration of Topical Steroid for Prurigo Nodularis

5 citations, January 2018 in “PubMed”

Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.