The Use of Biodegradable Microneedle Patches to Increase Penetration of Topical Steroid for Prurigo Nodularis

February 2018 in “ PubMed ”

Jung U Shin, Jung Dong Kim, Hong Kee Kim, Hong Kyu Kang, Chulmin Joo, Ju Hee Lee, Do Hyeon Jeong, Seungri Song, Howard Chu, Jungsoo Lee, Hemin Lee, Kwang Hoon Lee

biodegradable microneedle patches topical steroids prurigo nodularis mometasone furoate in vitro test clinical study lesion reduction pruritus scores refractory skin diseases MN patches steroid cream skin lesions itchiness

TLDR Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.

The study investigated the use of biodegradable microneedle (MN) patches to enhance the penetration of topical steroids in treating prurigo nodularis. It included an in vitro test and a clinical study with 24 East Asian patients. The in vitro results showed increased steroid penetration with MN patches. Clinically, patients applied mometasone furoate cream twice daily, with MN patches weekly on one side of the body. After four weeks, the MN-treated side showed significantly greater lesion reduction and lower pruritus scores. The study concluded that MN patches could improve treatment for refractory skin diseases like prurigo nodularis.

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research The Use of Biodegradable Microneedle Patches to Increase Penetration of Topical Steroid for Prurigo Nodularis

5 citations , February 2018 in “PubMed”

Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.