In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel With Reduced Runoff for Eyebrow Hair Growth

    March 2023 in “ Gels ”
    Luciano C. G. Xavier, Breno N. Matos, Geisa N. Barbalho, Manuel A. Falcão, Marcilio Cunha-Filho, Tais Gratieri
    TLDR The new minoxidil gel reduces runoff and improves eyebrow hair growth.
    The study developed a novel minoxidil thermosensitive gel (16% PLX, 0.4% HPMC) aimed at reducing runoff and enhancing eyebrow hair growth. Compared to a control formulation (4% PLX, 0.7% HPMC), the test gel showed significantly less runoff (7.2 mm vs. 15.8 mm at 1 min), better skin penetration, and retention of minoxidil (p < 0.05). Both formulations were non-irritating. The findings suggest that the new gel formulation could be a more effective and user-friendly option for topical minoxidil application.
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