In Vitro Performance Analysis of a Minoxidil Thermosensitive Gel With Reduced Runoff for Eyebrow Hair Growth

The study developed a novel minoxidil thermosensitive gel (16% PLX, 0.4% HPMC) aimed at reducing runoff and enhancing eyebrow hair growth. Compared to a control formulation (4% PLX, 0.7% HPMC), the test gel showed significantly less runoff (7.2 mm vs. 15.8 mm at 1 min), better skin penetration, and retention of minoxidil (p < 0.05). Both formulations were non-irritating. The findings suggest that the new gel formulation could be a more effective and user-friendly option for topical minoxidil application.