TLDR The nanoemulsion with garlic oil, apple cider vinegar, and minoxidil could effectively treat alopecia areata.
The study developed and optimized a nanoemulsion containing garlic oil (GO), apple cider vinegar (APCV), and minoxidil (MX) to treat alopecia areata. The optimal formulation, with 0.180% GO, 0.500% Smix, and 0.320% APCV, had a droplet size of 110 nm, MX steady-state flux (Jss) of 3 μg/cm²/h, and a minimum inhibitory concentration (MIC) of 0.275 μg/mL against Propionibacterium acnes. The nanoemulsion showed enhanced stability and significantly improved MX skin permeation (2.12-fold increase) compared to aqueous dispersion, following the Korsmeyer–Peppas model of super case II transport. These results suggest that the MX-GO-APCV nanoemulsion could effectively enhance MX delivery and its therapeutic effects for alopecia areata.
117 citations
,
August 2019 in “Drug Design Development and Therapy” Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.
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,
August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
19 citations
,
January 2012 in “International Journal of Trichology” Propionibacterium acnes might be linked to hair casts and possibly alopecia.
26 citations
,
June 2011 in “International Journal of Pharmaceutics” SLN suspensions work as well as commercial solutions for minoxidil delivery, but are non-corrosive, making them a promising alternative.
128 citations
,
July 2009 in “International Journal of Pharmaceutics” PEVs improve minoxidil skin penetration, increasing hair growth.
61 citations
,
January 2007 in “Indian Journal of Dermatology Venereology and Leprology” Garlic gel with betamethasone cream significantly improves hair regrowth in alopecia areata.
71 citations
,
January 1998 in “Pathobiology” The document concludes that certain rats and mice are useful for studying hair loss in humans and testing treatments.
13 citations
,
August 1991 in “The Journal of the American Osteopathic Association”
7 citations
,
December 2021 in “Pharmaceutics” The nanoemulsion with garlic oil, apple cider vinegar, and minoxidil could effectively treat alopecia areata.
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,
December 2013 in “Drug Delivery and Translational Research” Niosomes improve minoxidil skin penetration for hair loss treatment.
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,
October 2013 The new hydrogel and microemulsion could be better for hair loss treatment than current solutions.
