Preparation and Optimization of Garlic Oil/Apple Cider Vinegar Nanoemulsion Loaded with Minoxidil to Treat Alopecia

December 2021 in “ Pharmaceutics ”

Waleed Y. Rizg, Khaled M. Hosny, Samar S Elgebaly, Abdulmohsin J. Alamoudi, Raed Felimban, Hossam H. Tayeb, Majed G. Alharbi, Haitham A Bukhary, Walaa A. Abualsunun, Alshaimaa M. Almehmady, Rasha A Khallaf

garlic oil apple cider vinegar minoxidil alopecia areata nanoemulsion Propionibacterium acnes Korsmeyer–Peppas model super case II transport GO APCV MX

From the encyclopedia

Apple Cider Vinegar →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study developed a nanoemulsion of garlic oil and apple cider vinegar loaded with minoxidil to enhance drug permeation through skin, reporting improved ex vivo skin permeation parameters compared to an aqueous dispersion of minoxidil, suggesting potential benefits for treating alopecia areata.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

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research Is Propionibacterium Acnes Associated With Hair Casts And Alopecia?

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This case series suggests that Propionibacterium acnes colonization may contribute to the development of hair casts and diffuse non-scarring alopecia, as patients' symptoms improved with antibiotics targeting the bacteria.

research Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

26 citations , June 2011 in “International Journal of Pharmaceutics”

This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

128 citations , July 2009 in “International Journal of Pharmaceutics”

This study found that penetration enhancer-containing vesicles significantly improved minoxidil delivery to the skin compared to traditional liposomes and penetration enhancer-containing ethanolic solutions, with deformability linked to enhanced deposition.

research Combination of Topical Garlic Gel and Betamethasone Valerate Cream in the Treatment of Localized Alopecia Areata: A Double-Blind Randomized Controlled Study

61 citations , January 2007 in “Indian Journal of Dermatology Venereology and Leprology”

This study found that garlic gel significantly improved the efficacy of topical betamethasone valerate in treating alopecia areata compared to placebo.

research Evidence-Based Treatment of Alopecia Areata

12 citations , October 2001 in “Journal of the American Academy of Dermatology”

Topical 5% minoxidil lacks strong evidence for treating alopecia areata.

research Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species

71 citations , January 1998 in “Pathobiology”

This review discusses the use of animal models to study alopecia areata and reports no new experimental results, emphasizing the potential for these models to explore the disease's genetics and treatment.

research Cutaneous Immunopathology of Androgenetic Alopecia

13 citations , August 1991 in “The Journal of the American Osteopathic Association”

This research found evidence of inflammatory involvement in androgenetic alopecia, with higher deposition of certain immune components in the scalp of affected patients compared to those without baldness.