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This study found that topically applied liposomal spherical nucleic acids targeting the IL-17 receptor could effectively reduce psoriasis severity in preclinical models.

This study concluded that the KNPs@M/G microneedle system offers a promising strategy for treating radiation-induced skin injury by promoting antioxidative, anti-inflammatory, and regenerative effects.

In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.

This article discusses advancements and methodologies in epitope identification for autoimmune diseases, specifically alopecia areata, but does not report new experimental results.

This review discusses the potential of microneedles to enhance transdermal drug delivery by expanding the range of deliverable drugs, highlighting fabrication methods, material choices, and applications, but notes existing challenges with sustained delivery, cost-effectiveness, and large-scale production.

Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.

This research highlights major advancements in vaccinology, such as mRNA vaccines and nanoparticle delivery systems, enhancing vaccine efficacy and paving the way for novel vaccine development against infectious and non-infectious diseases like cancer, with implications for improved global health outcomes.

In this study, researchers prepared a humanized CXCL12 antibody for alopecia areata treatment, finding it significantly delayed disease onset in mice and reduced immune cell activation, suggesting potential as an immune modulatory therapy.

This review highlights recent advancements in microneedle technology, noting its ability to enhance transdermal drug delivery, biosensing, cancer treatment, and skin disease repair, while emphasizing its potential for improving patient compliance and reducing side effects.

This review discusses nanoparticle-based topical delivery systems for treating skin diseases and presents no new clinical findings; it emphasizes natural polymer-based nanoparticles and future applications like targeted drug delivery.

Nanoparticles have diverse applications, including promising cancer treatments and hair growth solutions.

This essay reviews the potential of protein microarrays in proteomics and diagnostics, highlighting no new clinical results but emphasizing the need for advanced high-quality proteins and antibodies.

This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.

This review highlights the potential of microneedle devices in dermatology for conditions like skin aging and autoimmune skin diseases, emphasizing their ability to facilitate targeted drug delivery by creating temporary skin pathways.

In this review, researchers explored thermo-responsive polymers and their applications in nanomedicine, highlighting their role in targeted drug delivery, gene therapy, and imaging, enabled by their temperature-sensitive phase transitions to ensure localized therapeutic action and minimize damage to healthy tissues.

This study found that ILC1-like cells can induce alopecia areata in healthy human hair follicles, suggesting that these cells might be a therapeutic target in AA management.

This review summarizes the pathophysiology and immune mechanisms of inflammatory skin diseases like psoriasis and atopic dermatitis, highlighting the therapeutic potential of targeted immunotherapies, but reports no new clinical results.

This study found that water-filtered infrared A radiation can induce the release of a model drug from gold nanoparticle-doped particles in hair follicles in an ex vivo porcine skin model, suggesting feasibility for follicular drug delivery systems.

This source reports on advances in stimulus-responsive nanoparticle-based PROTACs (nano-PROTACs), which aim to overcome existing challenges like poor cell permeability and systemic off-target effects by enabling controlled protein degradation through endogenous or exogenous stimuli, potentially enhancing therapeutic efficacy and reducing toxicity.

This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.

This review discusses the range of cutaneous immune-related adverse events induced by immune checkpoint inhibitors and the proposed mechanisms underlying these skin reactions, but reports no new clinical results.

This study reviews potential immune targets within hair follicles in alopecia areata, suggesting they may be associated with keratinocytes or melanocytes, and notes possible induction triggers like viruses and infections.

This study highlights the clinical potential of microneedles as an innovative transdermal drug delivery system for treating various skin diseases with minimal pain and high patient compliance.

This study found that tumor immunotherapy, while effective against solid tumors, can disrupt the immune balance in hair follicles, causing follicular toxicity and alopecia, highlighting the need for targeted interventions to manage these adverse effects.

This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

This study describes and characterizes four cases of alopecia areata induced by immune checkpoint inhibitor therapy in cancer patients, highlighting the importance of recognizing and managing these hair-related adverse events.

This study suggests that chitosan-enhanced human serum albumin nanoparticles could serve as a safe and effective carrier for delivering anticancer drugs like tamoxifen.

This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.

In this study, researchers explored the immunological mechanisms involved in alopecia areata and suggested that targeting immune responses, particularly using JAK inhibitors and other immunomodulatory drugs, could help achieve stable remission and improve patients' quality of life.