Immune Microenvironment of Hair Follicles in Tumor Immunotherapy

    February 2026 in “ ImmunoTargets and Therapy ”
    Bo Li, Wenxia Li, Fan Yang … Jianmin Chang
    Studysummary This study found that tumor immunotherapy, while effective against solid tumors, can disrupt the immune balance in hair follicles, causing follicular toxicity and alopecia, highlighting the need for targeted interventions to manage these adverse effects.
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    Research cited in this study 24

    1. RNase L Represses Hair Follicle Regeneration Through Altered Innate Immune Signaling Journal of Clinical Investigation · 2025
    2. Advances in Topical Therapies for Clinically Relevant and Prevalent Forms of Alopecia Life · 2024
    3. Alopecia and Hair Repigmentation Associated with Anti-Programmed Death-Ligand 1 (PD-L1) Immunotherapy JAAD Case Reports · 2024
    4. Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics International Journal of Molecular Sciences · 2024
    5. Stimulation of Mouse Hair Regrowth by Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Acta Histochemica · 2024
    6. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    7. Regulatory T Cells in Skin Mediate Immune Privilege of the Hair Follicle Stem Cell Niche Science Immunology · 2024
    8. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview Biomolecules · 2023
    9. Hdac1 and Hdac2 Regulate the Quiescent State and Survival of Hair-Follicle Mesenchymal Niche Nature communications · 2023
    10. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12) International Journal of Molecular Sciences · 2022
    11. Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus BMC Genomics · 2022
    12. Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis Cell Stem Cell · 2021
    13. Dermal Macrophage and Its Potential in Inducing Hair Follicle Regeneration Molecular Immunology · 2021
    14. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    15. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020
    16. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    17. Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails American Journal of Clinical Dermatology · 2018
    18. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    19. NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    20. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    21. LHX2 Is a Direct NF-κB Target Gene That Promotes Primary Hair Follicle Placode Down-Growth Development · 2016
    22. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    23. Cyclosporine A Increases Hair Follicle Growth by Suppressing Apoptosis-Inducing Factor Nuclear Translocation: A New Mechanism Fundamental & clinical pharmacology · 2015
    24. Cyclosporine A Stimulated Hair Growth from Mouse Vibrissae Follicles in an Organ Culture Model Journal of Nanjing Medical University · 2012