RNase L Represses Hair Follicle Regeneration Through Altered Innate Immune Signaling

    February 2025 in “ Journal of Clinical Investigation ”
    Charles S. Kirby, Nasif Islam, Eric M. Wier … Luis A. Garza
    Studysummary This study found that RNase L acts as a regeneration repressor gene in mammals, as seen in Rnasel-/- mice which showed increased regenerative capacity and elevated Wound Induced Hair Neogenesis through enhanced IL-36α signaling, suggesting a tradeoff between regeneration and immune regulation.
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