Merkel Cell Carcinoma: Updates in Tumor Biology, Emerging Therapies, and Preclinical Models

    July 2024 in “ Frontiers in Oncology
    Elisabeth A. Pedersen, Monique Verhaegen, Mallory Joseph … Paul W. Harms
    Studysummary This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 3

    1. Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2022
    2. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016
    3. Ectopic Atoh1 Expression Drives Merkel Cell Production in Embryonic, Postnatal, and Adult Epidermis Development · 2015