Ectopic Atoh1 Expression Drives Merkel Cell Production in Embryonic, Postnatal, and Adult Epidermis

    January 2015 in “ Development ”
    Stephen M. Ostrowski, Margaret C. Wright, Alexa M. Bolock … Stephen M. Maricich
    Studysummary This study found that inducing Atoh1 expression in transgenic mice is sufficient to generate new Merkel cells in the epidermis, with variations by skin location, developmental age, and hair cycle stage.
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    Research cited in this study 4

    1. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons Cell · 2011
    2. Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1 Development · 2010
    3. Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators Developmental dynamics · 2000
    4. Dynamics of Merkel Cell Patterns in Developing Hair Follicles in the Dorsal Skin of Mice, Demonstrated by a Monoclonal Antibody to Mouse Keratin 8 Cells Tissues Organs · 1995

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