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    Glossary Immune Cell Infiltration

    movement of immune cells into tissues responding to damage or infection

    Immune cell infiltration refers to the process where immune cells, such as T cells and macrophages, move into a tissue or organ, often in response to infection, injury, or disease. This can be a sign of the body's attempt to fight off pathogens or repair damage, but in some cases, like autoimmune diseases, it can lead to tissue damage and inflammation.

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    1. Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege International Journal of Cosmetic Science · 2024
    2. A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin Biofabrication · 2024 · 6 citations
    3. 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases Journal of Investigative Dermatology · 2017
    4. Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo Journal of Investigative Dermatology · 2026
    5. Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis Annals of Translational Medicine · 2022
    6. Spatial transcriptome reveals disturbance of peri-infundibular immune infiltration in androgenetic alopecia Research Square (Research Square) · 2023
    7. Identification and characterization of four immune-related signatures in keloid Frontiers in Immunology · 2022 · 11 citations
    8. Hair follicle plasticity with complemented immune-modulation following follicular unit extraction International Journal of Trichology · 2015 · 4 citations
    9. Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms Precision clinical medicine · 2023 · 3 citations
    10. Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model International Journal of Molecular Sciences · 2024
    11. TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cells Research Square (Research Square) · 2023
    12. 1391 Immune cells may have a role in hair loss process caused by TRPV3 gain-of-function mutation Journal of Investigative Dermatology · 2018
    13. 0150 Single-cell and spatial transcriptome profiling reveals innate-adaptive crosstalk in alopecia areata Journal of Investigative Dermatology · 2025
    14. Immune response involving the bulge region in addition to telogen conversion contributes to hair loss in a case of atypical drug-induced hypersensitivity syndrome The Journal of Dermatology · 2013 · 1 citations
    15. Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics International Journal of Molecular Sciences · 2024
    16. Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    17. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy Cell death and differentiation · 2015 · 56 citations
    18. Stress, Hair Growth Control, and the Neuro-Endocrine-Immune Connection Allergo Journal · 2000 · 7 citations
    19. Alopecia areata but not androgenetic alopecia is characterized by a restricted and oligoclonal T-cell receptor-repertoire among infiltrating lymphocytes Journal of Cutaneous Pathology · 1997 · 19 citations
    20. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts 1998 · 131 citations
    21. Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis 2013 · 51 citations
    22. Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation Scientific Reports · 2017 · 27 citations
    23. Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue International Journal of Molecular Sciences · 2018 · 18 citations
    24. Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture 2014 · 15 citations
    25. Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling Biomolecules · 2022 · 13 citations
    26. Retinoids Putting the “A” in Alopecia Journal of Investigative Dermatology · 2013 · 7 citations
    27. Delayed Collagen Production without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Microwounds Journal of Investigative Dermatology · 2023 · 5 citations
    28. Lichen planopilaris International Journal of Dermatology · 2001 · 5 citations
    29. Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing Research Square (Research Square) · 2020 · 2 citations
    30. Frontal fibrosing alopecia: A review of disease pathogenesis Frontiers in Medicine · 2022 · 2 citations