64 citations
,
August 1977 in “PubMed” This article describes the skin changes seen in acute and chronic graft-vs-host reactions after bone marrow transplantation, highlighting the potential for early recognition due to the visibility of these changes, but reports no new clinical results.
28 citations
,
January 2021 in “Burns & Trauma” This study found that wound healing after scald burns in mice was slower in deeper burns, but the healing quality in second-degree deep scalds was similar to normal healing.
January 2009 in “Junshi Yixue Kexueyuan yuankan” This study found that implanting hair follicle dermal sheath cells in rat skin wounds significantly accelerated wound contraction and healing compared to controls.
201 citations
,
April 2017 in “Regeneration” This review examines the roles of macrophages and fibroblastic cells in organ injury and repair, discussing their impact on outcomes ranging from regeneration to fibrosis, without presenting new clinical results.
6 citations
,
June 2022 in “Frontiers in Bioengineering and Biotechnology” This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.
January 2025 in “Indian Journal of Paediatric Dermatology” In this case report, researchers described a rare instance of granuloma annulare in a six-year-old child mimicking alopecia mucinosa, highlighting the importance of clinicopathologic correlation in diagnosing dermatological conditions. Treatment with topical mometasone furoate led to a satisfactory improvement and complete resolution within seven months.
4 citations
,
February 2020 in “Journal of Cosmetic Dermatology” This study reported significant moderate-to-severe complications in two patients following synthetic hair fiber implantation, including recurrent infections, scalp issues, and granulomatous reactions, which were only resolved once the fibers were removed despite initial treatment attempts with antibiotics.
7 citations
,
January 2018 in “Journal of Tissue Viability” This case report describes an 80-year-old patient whose scalp wound healed by secondary intention, with unexpected hair regrowth observed at 180 days, suggesting hair neogenesis is possible even in older adults.
5 citations
,
September 2019 in “ACS Applied Bio Materials” This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.
527 citations
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December 2011 in “Proceedings of the National Academy of Sciences” This study found that dextran-based hydrogels promoted significant neovascularization and skin regeneration in mouse models of third-degree burns, without the need for additional growth factors or cells.
3 citations
,
December 2013 in “American Journal of Dermatopathology” This case report describes a unique lesion in a 10-month-old girl, characterized by increased eccrine glands and hair follicles, leading to the proposed term "hybrid eccrine gland and hair follicle hamartoma".
September 2017 in “Journal of Investigative Dermatology” This study found that hyaluronic acid increased the size and cell proliferation of mixed aggregates in a 3D culture model, indicating its role in human hair follicle germ-like structure formation without enhancing dermal papilla cell markers.
2 citations
,
January 2022 in “Experimental Dermatology” This paper proposes that GDNF signaling may enhance skin regeneration and hair follicle formation by influencing dermal fibroblast differentiation, particularly following injury.
January 2011 in “Journal of The American Academy of Dermatology” Treating generalized granuloma annulare is difficult, with PUVA being the most effective option, but relapses are common.
July 2023 in “Clinical Cosmetic and Investigational Dermatology” In this case report, a 64-year-old Thai woman with a history of misdiagnosed eczema or folliculitis was ultimately found to have granular parakeratosis of the eccrine ostium, leading to significant symptom improvement once accurately diagnosed and advised to avoid excessive heat and moisture.
4 citations
,
March 2011 in “European Journal of Dermatology” Trauma can cause fat inflammation and abnormal hair growth.
7 citations
,
November 2020 in “Experimental Dermatology” This article reviews skin regeneration and fibrosis, identifying key cellular and molecular players, and emphasizing the potential to manipulate the postwound environment to promote regeneration over fibrosis.
August 2024 in “Nature Communications” This study found that in female mice, softer, lightly crosslinked gelatin-based hydrogels promoted better wound healing with less scarring and inflammation compared to stiffer, heavily crosslinked hydrogels, affecting immune and stromal cell behavior.
3 citations
,
November 2021 in “Journal of biomedical materials research. Part B, Applied biomaterials” In a rabbit model, this study found that the AMFIBHA skin substitute promoted wound healing and regeneration of skin structures in large-area third-degree burn wounds, suggesting potential clinical use.
July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that although mature neutrophils and NETs are stimulated by a pro-regenerative cue, their presence actually hinders wound-induced hair follicle regeneration.
5 citations
,
October 2012 in “The Journal of Dermatology” This letter to the editor presents two new cases of traumatic panniculitis with localized hypertrichosis and provides clinical considerations, but it does not report experimental findings.
June 2025 in “Biomacromolecules” In this study, researchers developed a GelMA-based gradient pH hydrogel that effectively reduced bacterial load and promoted fibroblast and endothelial cell proliferation, macrophage polarization, neovascularization, and hair follicle regeneration, offering a promising treatment for bacterially infected skin wounds.
4 citations
,
February 2011 in “Dermatology reports” In this study, oral acitretin therapy for psoriasis was associated with excess granulation tissue in the nail sulcus and noncicatricial universal alopecia.
733 citations
,
September 2009 in “Journal of Cell Science” This article reviews the complex process of wound repair, emphasizing recent microarray studies and proteomic analyses, but reports no new clinical results.
21 citations
,
July 2024 in “Journal of Investigative Dermatology” This study used single-cell RNA-sequencing data from mouse skin to reveal that fibroblasts show high transcriptional plasticity during wound healing, forming transient microniches early on and stratifying scar tissue into distinct molecular layers over time.
January 2016 in “Springer eBooks” New materials and methods could improve skin healing and reduce scarring.
5 citations
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March 2013 in “Journal of Cutaneous Pathology” Granulomatous alopecia may be a distinct subtype of alopecia areata.
June 2018 in “Journal of Clinical Periodontology” A patient with "strawberry gingivitis" improved after correct treatment for Granulomatosis with polyangiitis, highlighting the need for early diagnosis.
24 citations
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October 2010 in “Tissue Engineering Part A” This study found that tissue-engineered skin using mouse fibroblasts successfully supported hair growth after grafting, but similar success was not observed using human fibroblast-derived tissue.
6 citations
,
September 1993 in “The Journal of Dermatologic Surgery and Oncology” This article suggests that using cyanoacrylate adhesives may improve the cosmetic appearance of hair transplants by preventing graft elevation or cobblestoning, though no new research data was reported.