Gradient pH Hydrogel Promotes Infected Wound Healing Through pH Regulation of Microenvironment

The study investigates the use of a GelMA-based gradient pH hydrogel for healing infected skin wounds. The hydrogel effectively lowers the pH of the wound bed, which reduces bacterial load and promotes the proliferation and migration of fibroblasts and endothelial cells. It also induces macrophage polarization to M2 and supports neovascularization. Notably, the hydrogel aids in hair follicle regeneration by modulating Treg cells, offering a promising new treatment option for bacterially infected wounds.