Gradient pH Hydrogel Promotes Infected Wound Healing Through pH Regulation of Microenvironment

    June 2025 in “ Biomacromolecules ”
    Yan Yang, Shizhuo Li, Yixuan Li, Mengyue Zhang, Shitong Li, Kun Liu, Tong Qiu, Honglian Dai
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    Studysummary In this study, researchers developed a GelMA-based gradient pH hydrogel that effectively reduced bacterial load and promoted fibroblast and endothelial cell proliferation, macrophage polarization, neovascularization, and hair follicle regeneration, offering a promising treatment for bacterially infected skin wounds.
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    The study investigates the use of a GelMA-based gradient pH hydrogel for healing infected skin wounds. The hydrogel effectively lowers the pH of the wound bed, which reduces bacterial load and promotes the proliferation and migration of fibroblasts and endothelial cells. It also induces macrophage polarization to M2 and supports neovascularization. Notably, the hydrogel aids in hair follicle regeneration by modulating Treg cells, offering a promising new treatment option for bacterially infected wounds.
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