Neutrophil Extracellular Traps Impair Regeneration

July 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Eric M. Wier, Mayumi Asada, Gaofeng Wang, Martin P. Alphonse, Ang Li, Chase Hintelmann, Christine Youn, Brittany Pielstick, Roger V. Ortines, Lloyd S. Miller, Nathan K. Archer, Luis A. Garza

neutrophil extracellular traps NETs wound induced hair follicle regeneration WIHN neutrophils Pad4 null mice

TLDR Neutrophil extracellular traps slow down hair follicle healing after injury.

The study "Neutrophil extracellular traps impair regeneration" conducted by Asada, Wang, Alphonse, Li, Hintelmann, Youn, Pielstick, Ortines, Miller, Archer, and Garza in 2020, investigated the role of neutrophils and neutrophil extracellular traps (NETs) in wound induced hair follicle regeneration (WIHN). The researchers found that while mature neutrophils were present shortly after wounding and remained within the wound after the barrier was reestablished, their presence and the production of NETs actually hindered WIHN. This was contrary to their initial hypothesis that mature neutrophils and NETs might promote WIHN. This conclusion was supported by the observation that genetic models of neutrophil depletion showed enhanced WIHN, and Pad4 null mice that are defective in NET production also showed improved WIHN.

View this study on biorxiv.org →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3

47 citations, June 2019 in “Nature Communications”

Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.

research Comparative Regenerative Biology of Spiny (Acomys Cahirinus) and Laboratory (Mus Musculus) Mouse Skin

37 citations, February 2019 in “Experimental Dermatology”

Spiny mice are better at regenerating hair after injury than laboratory mice and could help us understand how to improve human skin repair.

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

145 citations, November 2018 in “Nature Communications”

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

research M2 Macrophages Promote Wound-Induced Hair Neogenesis

27 citations, May 2018 in “Journal of Dermatological Science”

M2 macrophages, a type of immune cell, help in new hair growth on scars by producing growth factors.

research Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner

36 citations, April 2018 in “Journal of Investigative Dermatology”

Macrophages help hair growth after injury through CX3CR1 and TGF-β1.

research After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration

27 citations, April 2017 in “Journal of Investigative Dermatology”

After skin is damaged, noncoding dsRNA helps prostaglandins and Wnts work together to repair tissue and promote hair growth.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations, March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations, January 2017 in “Science”

Some wound-healing cells can turn into fat cells around new hair growth in mice.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations, August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations, June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

418 citations, September 2012 in “Nature”

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

research Characterization and Quantification of Wound-Induced Hair Follicle Neogenesis Using In Vivo Confocal Scanning Laser Microscopy

26 citations, April 2011 in “Skin Research and Technology”

In vivo confocal scanning laser microscopy is an effective, non-invasive way to study and measure new hair growth after skin injury in mice.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research The Formation of Vellus Hair Follicles from Human Adult Epidermis

73 citations, July 1956 in “Journal of Investigative Dermatology”

Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.

Similar Research

5 / 1000+ results

research Neutrophil Extracellular Traps Impair Regeneration

4 citations, October 2021 in “Journal of Cellular and Molecular Medicine”

White blood cells and their traps can slow down the process of new hair growth after a wound.

research TLR9 Activation in Large Wound Induces Tissue Repair and Hair Follicle Regeneration via γδT Cells

August 2024 in “Cell Death and Disease”

Activating TLR9 helps heal wounds and regrow hair by using specific immune cells.

research Role of Fibroblast DPP4 in Wound Healing, Scarring, and Regeneration

April 2018 in “Journal of Investigative Dermatology”

DPP4 is important for scarring and skin regeneration, and managing its activity could improve skin healing treatments.

research Dynamic Morphogen-p63 Chromatin Interactions That Guide Epigenetic Changes and p63 Activity in Surface Ectoderm Commitment