Graft-Versus-Host Reaction: Cutaneous Manifestations Following Bone Marrow Transplantation
August 1977
in “
PubMed
”
graft-versus-host reaction GVHR cutaneous manifestations bone marrow transplantation macular erythema erythematous papules violaceous macules vacuolar changes epidermal basal-cell layer lymphocyte infiltrates generalized scaling sclerotic skin atrophic skin hyperpigmentation ulcerations alopecia dermal collagenization skin changes hair loss
Studysummary This article describes the skin changes seen in acute and chronic graft-vs-host reactions after bone marrow transplantation, highlighting the potential for early recognition due to the visibility of these changes, but reports no new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document described the cutaneous manifestations of graft-versus-host reaction (GVHR) in two patients following bone marrow transplantation for aplastic anemia. Acute GVHR presented as macular erythema or erythematous papules and violaceous macules with scale, with skin biopsies showing vacuolar changes in the epidermal basal-cell layer and lymphocyte infiltrates. Chronic GVHR evolved from generalized scaling to sclerotic and atrophic skin with hyperpigmentation, ulcerations, and alopecia, with histopathology revealing dermal collagenization. The visibility of skin changes allowed for early recognition of GVHR.
