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GlossaryLymphocyte Infiltration

process where white blood cells accumulate in tissue

Lymphocyte infiltration refers to the process where lymphocytes, a type of white blood cell, move into and accumulate in a specific tissue or organ. This often occurs in response to infection, inflammation, or autoimmune conditions, where the immune system targets the body's own cells. In the context of alopecia, lymphocyte infiltration can lead to hair follicle damage, contributing to hair loss.

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research Graft-Versus-Host Reaction: Cutaneous Manifestations Following Bone Marrow Transplantation

64 citations, August 1977 in “PubMed”

Skin changes help detect graft-versus-host reaction early after bone marrow transplants.

research Follicular Mycosis Fungoides Mimicking a Cutaneous B-Cell Lymphoproliferative Disorder

14 citations, July 2004 in “Australasian Journal of Dermatology”

Follicular mycosis fungoides can look like a B-cell lymphoma, making diagnosis difficult.

research Restoration of Hair Growth with Topical Diphenylcyclopropenone in Mouse and Rat Models of Alopecia Areata

12 citations, December 2003 in “Journal of the American Academy of Dermatology”

Topical diphencyprone helped regrow hair in mice and rats with a condition similar to human hair loss.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations, March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

33 citations, July 1992 in “Journal of Investigative Dermatology”

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 1 month ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 44 upvotes 3 weeks ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 3 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.