The Role of Hair Follicle Dermal Sheath Cells in Rat Skin Wound Healing: An Experimental Study

January 2009 in “ Junshi Yixue Kexueyuan yuankan ”

Li You

hair follicle dermal sheath cells wound healing granulation tissue epidermis regeneration collagen deposition tissue reconstruction apoptosis

TLDR Hair follicle dermal sheath cells speed up skin wound healing.

The study investigated the role of hair follicle dermal sheath cells in wound healing using 22 Wistar rats. Dermal sheath cells were cultured, labeled, and implanted into skin wounds, with the opposite side treated with saline as a control. Results showed that the wound contraction rate was significantly higher in the implanted group compared to the control group. Seven days post-operation, implanted cells were present in granulation tissues, and by 14 days, they were reduced and showed signs of apoptosis. Pathological studies indicated that the implanted group experienced faster healing, with enhanced granulation tissue formation, epidermis regeneration, collagen deposition, and tissue reconstruction. The study concluded that hair follicle dermal sheath cells could accelerate wound contraction and promote skin wound healing.

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