Silymarin Enhanced Fibroblast Proliferation and Tissue Regeneration in Full Thickness Skin Wounds in Rat Models: A Stereological Study

The study on 36 male Wistar rats found that a 2% silymarin (SM) gel significantly improved wound healing by enhancing fibroblast proliferation, collagen synthesis, and increasing the volume density of hair follicles by 78.6% compared to controls. While SM did not significantly affect blood vessel parameters, its anti-inflammatory and antioxidative properties contributed to better wound closure rates. The study suggested SM as a potential alternative treatment for skin wounds, though further research was needed to evaluate its safety and efficacy in humans.