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This study found that sex hormones, specifically non-aromatizable androgens like DHT and A/T, significantly increase inflammatory cytokine expression in human adipocytes when stimulated by LPS.

This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.

This study found that leptin from dermal white adipose tissue may regulate hair growth and cycle progression through its receptor on hair follicle epithelium in mice and humans.

This study developed a carbohydrate chitosan-based biomaterial combined with a novel peptide to promote the chondrogenic differentiation of human adipose-derived stem cells, suggesting potential clinical applications for cartilage regeneration.

This review discusses the potential effectiveness of cell therapy for hair loss, highlighting promising early findings but emphasizing that more research is needed to explore specific therapies like autologous fat grafting and mesenchymal stem cells.

This review reports that exosomes show potential in regenerative and cosmetic dermatology for applications like wound healing and hair loss mitigation, but their clinical use is currently limited by high costs, complex processing, and sparse clinical evidence.

This systematic review found that both cellular and acellular stem cell-based therapies are safe and able to improve hair regeneration and density in patients with androgenic alopecia, although some results may be temporary.

This study found that extracellular vesicles derived from hair follicle mesenchymal stromal cells demonstrated similar potential to those from adipose tissue in promoting cell proliferation and migration, enhancing angiogenesis, and protecting cells under stress, suggesting promise for chronic wound treatment.

This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.

This review examines the mechanisms, recent findings, and strategies to enhance mesenchymal stem cells' therapeutic effects in skin wound healing, but reports no new research results.

This review reports that regenerative medicine, such as autologous stem cell micrografting and Rigenera®, may significantly improve hair density in individuals with androgenetic alopecia, highlighting its potential as a future therapeutic option that addresses current treatment limitations.

This review article summarizes the potential role of advanced medical therapies—using genes, cells, and/or tissue engineering—in treating various types of alopecia, by examining clinical research, basic studies, and ongoing trials.

This study found that treating patients with androgenetic alopecia using exosomes from adipose tissue stem cells over 24 weeks significantly increased hair density and patient satisfaction without severe adverse effects, suggesting a promising alternative treatment for hair loss.

This study found that encapsulating hADSCs-derived exosomes in PF-127 hydrogel improved wound healing in mice, suggesting a promising approach for enhancing skin repair.

This study found that human adipose-derived stem cells co-cultured on a collagen sponge scaffold showed increased differentiation into keratinocytes, suggesting potential for improved skin wound healing.

This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.

This review discusses the roles of dermal white adipose tissue (dWAT) as an insulator, antibiotic, and regenerative tissue, highlighting its importance in systemic metabolism and immune function, but reports no new clinical results.

This review explores the therapeutic potential of brown adipose tissue for treating polycystic ovary syndrome and reports no new experimental results, emphasizing the need for future research to develop effective strategies.

This review discusses the potential role of brown adipose tissue in managing polycystic ovary syndrome and reports no new clinical results; it highlights a need for further research on this therapeutic avenue.

In this study, adipose-derived stem cells from human scalp were successfully directed towards chondrocyte differentiation, with TGF-beta3 and BMP-6 growth factors proving effective for in vitro chondrogenesis.

This study found that human follicular papilla cells in the scalp produce leptin and express functional leptin receptors, suggesting leptin's significant role in hair biology.

This study examined aging hair follicle stem cells in mice and found that inflammation reduction in dermal white adipose tissue can stimulate regenerative behavior, highlighting its role in hair follicle aging.

In this study, researchers used a mouse model to identify an adipocyte-to-fibroblast conversion pathway that promotes mast-cell recruitment and dermal fibrosis in atopic dermatitis, suggesting a potential therapeutic approach to block this process and reduce inflammation and fibrosis.

This review discusses the roles of dermal white adipose tissue in skin functions and pathology, underscoring its antibacterial activity and potential anti-fibrotic role, but reports no new experimental results.

This review discusses different processing methods for isolating human AD-SVFs/AD-MSCs using various kits and reports no new clinical results, highlighting the need for standardized preparation techniques.

This review suggests that omitting the proteolysis step and including tissue pieces in mesenchymal stem cell isolation may improve cell quality, reduce contamination risk, and lower costs and processing time in clinical applications.

This study found that incorporating human adipose subcutaneous tissue in 3D organotypic skin cultures mimicking hypertrophic scar conditions improved epidermal homeostasis, formed a basement membrane similar to native skin, and reduced myofibroblast presence, indicating an anti-fibrotic effect.

This study evaluated adiponectin's effects on human hair follicles in vitro, indicating its role in the regulation of specific processes within adipose tissue.

This study reports that the mechanical interactions between human skin and adjacent subcutaneous white adipose tissue influence the appearance of skin wrinkles, with sWAT reinforcement potentially more effective for reducing signs of skin aging than skin reinforcement alone.

This review reports limited evidence suggesting that stem cell-based therapies, particularly using human-derived mesenchymal stem cells and exosomes, may be effective for skin rejuvenation, though results are uncertain due to methodological limitations and variability across studies.