3 citations
,
April 2011 in “Expert Review of Dermatology” This review examines a study showing that the balding scalp in men with androgenetic alopecia retains stem cells but lacks certain progenitor cells, suggesting new targets for future therapies; it reports no clinical results.
11 citations
,
May 2023 in “Proceedings of the National Academy of Sciences” This study found that hair follicle stem cells are stiff with high actomyosin contractility, while hair germ progenitors are soft and enlarge during quiescence, influencing hair regeneration; inducing miR-205 reduces contractility and activates regeneration in mice.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inducing miR-205 reduces actin contractility and stiffness in hair follicle stem cells and progenitors, stimulating hair regeneration in both young and old mice.
163 citations
,
April 2019 in “Nature Communications” This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.
23 citations
,
September 2015 in “International Journal of Molecular Medicine” This study found that the activation of ER‑β increased keratinocyte proliferation and gene expression related to epidermal regeneration, enhancing wound healing in both cell models and rats.
16 citations
,
September 2016 in “Neuropharmacology” This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.
175 citations
,
December 2014 in “PLoS Biology” This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.
71 citations
,
January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology” This study found that mTOR signaling plays a crucial role in activating hair follicle stem cells by balancing BMP-mediated repression, essential for hair regeneration.
54 citations
,
January 2016 in “Cell reports” This study found that different epidermal stem cell populations contribute to the formation of various skin tumors and new hair follicles following β-catenin activation in the adult epidermis.
27 citations
,
May 2017 in “Marine Drugs” This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.
11 citations
,
July 2015 in “Gene” This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.
14 citations
,
April 2016 in “Cell Transplantation” This study found that neural stem cell extract enhanced hair growth in mice and cells by stimulating hair follicle niches and activating signaling pathways like TGF-β and BMP.
April 2026 in “npj Regenerative Medicine” This review discusses the processes of melanocyte stem cell quiescence and activation, focusing on their interaction with hair follicle stem cells, and highlights current research on hair graying mechanisms; it reports no new results.
45 citations
,
September 2012 in “Life Sciences” This study observed that Aconiti Ciliare Tuber extract may promote hair growth in mice by activating the Wnt/β-catenin signaling pathway.
12 citations
,
June 2017 in “Cell Cycle” This study observed that 5% minoxidil topical foam alters gene expression and signaling pathways in the scalp, providing insights into its mechanism of action in men with androgenetic alopecia.
5 citations
,
October 2024 in “International Journal of Biological Sciences” This study found that a specific fragment of AIMP1, secreted by hair follicle stem cells, activated dermal papilla cells, leading to enhanced hair regrowth and maintenance in mice.
9 citations
,
June 2021 in “International Journal of Pharmaceutics” This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.
May 2023 in “Research Square (Research Square)” This study found that the natural product Shi-Bi-Man significantly promoted hair regeneration in cynomolgus monkeys, increasing hair follicle number and activation by boosting specific protein markers and interactions in Laminin-related pathways.
1 citations
,
October 2020 in “Journal of Cosmetic Dermatology” This study found that metabolic syndrome was more prevalent among androgenetic alopecia patients than controls, with higher serum RANTES levels suggesting a potential role in the syndrome's pathogenesis.
January 2026 in “Frontiers in Bioscience-Landmark” This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage.
96 citations
,
June 2017 in “Nature Communications” This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.
47 citations
,
December 2019 in “Frontiers in immunology” This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.
46 citations
,
June 2015 in “Journal of Investigative Dermatology” This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.
23 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses rodent models of alopecia areata and suggests they are crucial for understanding the autoimmune mechanisms and potential treatments but reports no new clinical results.
17 citations
,
September 2020 in “Inflammation and Regeneration” In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.
16 citations
,
September 2020 in “British journal of dermatology/British journal of dermatology, Supplement” This review explores the role of neutrophil recruitment in the inflammation seen in hidradenitis suppurativa and emphasizes potential therapeutic targets within these pathways, but it reports no new clinical results.
3 citations
,
July 2011 in “Expert Review of Dermatology” This article reviews the causes and treatments of hirsutism, emphasizing the importance of considering ethnic and cultural norms when interpreting grading systems, and reports no new original findings.
2 citations
,
February 2023 in “BMC women's health” In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.
2 citations
,
September 2019 in “South Asian research journal of pharmaceutical sciences” This article reviews the risks of metal exposure from cosmetic products and emphasizes the need for stricter regulation and consumer awareness, without presenting new data or results.
August 2024 in “Cell Death and Disease” This study found that toll-like receptor 9 plays a previously unrecognized role in sensing skin injury and influencing tissue repair and regeneration in adult mice by modulating γδT cell migration.