TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model

    September 2016 in “ Neuropharmacology ”
    Makoto Ishikawa, Takeshi Yoshitomi, Douglas F. Covey … Yukitoshi Izumi
    Studysummary This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.
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    Research cited in this study 5

    1. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model Investigative Ophthalmology & Visual Science · 2014
    2. Reversible Visual Loss Caused by Combination Therapy of Alfuzosin and Finasteride in a Patient with Uveitic Glaucoma Cutaneous and Ocular Toxicology · 2012
    3. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    4. Role of Neurosteroids in Regulating Cell Death and Proliferation in the Late Gestation Fetal Brain Neuroscience · 2009
    5. Comparison of Clinical Trials with Finasteride and Dutasteride PubMed · 2004

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    3. TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model Neuropharmacology · 2016