Metabolic Syndrome in Androgenetic Alopecia Patients: Is Serum Regulated on Activation, Normal T-Cell Expressed and Secreted the Missing Link?

October 2020 in “ Journal of Cosmetic Dermatology ”

Amany Ibrahim Mustafa, Walid A Abdel Halim, Fawzy Eman, Doaa M. Elhabak

androgenetic alopecia metabolic syndrome serum RANTES biomarker AGA

Studysummary This study found that metabolic syndrome was more prevalent among androgenetic alopecia patients than controls, with higher serum RANTES levels suggesting a potential role in the syndrome's pathogenesis. Our plain-language summary of this paper — not a Tressless recommendation.

The study suggests a potential link between androgenetic alopecia and metabolic syndrome, with higher levels of serum RANTES found in AGA patients with metabolic syndrome. RANTES may be the missing link between the two conditions. The study involved 80 participants with AGA and proposes that RANTES may be a valuable biomarker for identifying metabolic syndrome in individuals with androgenetic alopecia. However, more research is needed to confirm this connection.

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Research cited in this study

11 / 11 results

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

research Alopecia and Its Association with Coronary Heart Disease and Cardiovascular Risk Factors: A Meta-Analysis

48 citations , October 2014 in “International Journal of Cardiology”

This meta-analysis found that people with alopecia have an increased risk of coronary heart disease and several cardiovascular risk factors compared to those without alopecia.

research Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study

34 citations , January 2014 in “Indian Dermatology Online Journal”

This study supports evaluating metabolic syndrome and insulin resistance in young males with advanced androgenic alopecia to potentially reduce future cardiovascular and type 2 diabetes risks.

research Sex Hormone–Binding Globulin and Risk of Hyperglycemia in Patients With Androgenetic Alopecia

36 citations , April 2011 in “Journal of The American Academy of Dermatology”

People with hair loss have higher risk of high blood sugar and diabetes, and lower levels of a specific hormone.

research Androgenetic Alopecia and Insulin Resistance: Are They Truly Associated?

35 citations , March 2011 in “International Journal of Dermatology”

This study concluded that patients with metabolic syndrome, regardless of androgenetic alopecia presence, were more insulin resistant than those with only androgenetic alopecia or healthy controls, indicating no true association between alopecia and insulin resistance.

research Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey

69 citations , April 2010 in “British Journal of Dermatology”

This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.

research Hypertension and Aldosterone Levels in Women with Early-Onset Androgenetic Alopecia

45 citations , November 2009 in “British Journal of Dermatology”

This study found that women with early-onset androgenetic alopecia had higher aldosterone levels and blood pressure, suggesting a possible link to the increased prevalence of hypertension in this group.

research Androgenic Alopecia and Insulin Resistance: Are They Really Related?

28 citations , March 2009 in “Clinical and Experimental Dermatology”

This article discusses the potential relationship between androgenic alopecia and insulin resistance but presents no new clinical findings, calling for further research on the topic.

research Established Risk Factors for Coronary Heart Disease Are Unrelated to Androgen-Induced Baldness in Female-to-Male Transsexuals

57 citations , January 2004 in “Journal of Endocrinology”

This study found no support for the idea that male-pattern baldness in female-to-male transsexuals indicates an increased risk of coronary heart disease through androgenic effects on classic risk factors.

research Early Androgenetic Alopecia as a Marker of Insulin Resistance

115 citations , September 2000 in “The Lancet”

Early hair loss may indicate risk of insulin resistance.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

This article presents a classification system for stages of female-pattern androgenetic alopecia to aid early diagnosis and mentions existing systems for rare male-pattern cases, but reports no new clinical results.