Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling

    January 2026 in “ Frontiers in Bioscience-Landmark ”
    Zhenyan Piao, Dae Sung Yoo, Sang Hee Park, Dong Seon Kim, Si Eun Yoon, Ji Hye Yoon, Jongsung Lee, Jae‐Joong Kim, Jae Youl Cho
    New to Gotu Kola? There is a guide in the encyclopedia. Read the guide →
    Image
    Studysummary This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage. Our plain-language summary of this paper — not a Tressless recommendation.
    Araliadiol, a compound from Centella asiatica, demonstrates significant protective effects against skin damage caused by urban particulate matter (UPM) by reducing oxidative stress, DNA damage, and apoptosis in human keratinocytes. The study found that araliadiol enhances antioxidant defenses by upregulating genes like HO-1 and NQO1 and activating the Nrf2 and JNK–AP-1 signaling pathways. Unlike UPM exposure, which induces limited antioxidant responses, araliadiol independently activates robust cytoprotective mechanisms, highlighting its potential as a therapeutic agent for mitigating pollutant-induced skin damage.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results