75 citations
,
October 2010 in “Mammalian genome” In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.
69 citations
,
June 2017 in “Experimental Biology and Medicine” This review discusses the advancements and challenges in developing in vitro human skin models incorporating components like vasculature for drug testing and disease research, but reports no new clinical results.
68 citations
,
March 2018 in “Biomaterials” This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.
67 citations
,
September 2001 in “American Journal Of Pathology” This study found that overexpression of the enzyme ornithine decarboxylase in transgenic mice led to UVB-induced skin tumors, but this was prevented by the ODC inhibitor α-difluoromethylornithine.
66 citations
,
January 1987 in “Journal of Investigative Dermatology” This study found that enzyme activity critical to cancer induction by polycyclic aromatic hydrocarbons in human hair follicles increased after using a crude coal tar-containing shampoo for four days and was substantially inhibited by imidazole compounds.
62 citations
,
October 2016 in “Dermatologic Therapy” This study found that platelet-rich plasma was more effective for treating alopecia areata than topical 5% minoxidil, leading to earlier hair regrowth and reduction in hair abnormalities.
53 citations
,
May 2010 in “Journal of Cellular Physiology” This study found that mice lacking the Vitamin D receptor showed disrupted hair follicle cycling, which was partially restored with hedgehog signaling pathway activation, suggesting a role for this pathway in follicle regulation independent of vitamin D.
49 citations
,
February 2022 in “Drug Design Development and Therapy” This study found that treatment with ritlecitinib improved hair regrowth in alopecia areata patients, with many achieving significant results after 24 weeks compared to placebo.
41 citations
,
December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.
40 citations
,
June 2013 in “Scientific Reports” This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.
38 citations
,
August 2015 in “Drug Design Development and Therapy” This study observed that topical flutamide may be as effective as hydroquinone for treating melasma, with a trend towards greater improvement and patient satisfaction, but recommends further research before clinical use.
36 citations
,
January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the connection between PI3K-AKT-mTOR pathway mutations and heritable skin diseases characterized by tissue overgrowth, but it reports no new clinical results.
33 citations
,
July 2007 in “Skin research and technology” The study found that the break force of human hair significantly depends on hair diameter and strain, but not on age, gender, use of hair dye, or drugs.
32 citations
,
May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
30 citations
,
December 1999 in “International Journal of Dermatology” In this uncontrolled study, ivermectin treatment for scabies resulted in the resolution of symptoms and negative skin scrapings in most patients at follow-ups.
27 citations
,
February 2014 in “BMC Cancer” The EPICAP study aims to investigate various factors influencing prostate cancer, including circadian disruption, inflammation, hormonal and metabolic factors, and genetic susceptibility, and reports no new clinical results.
24 citations
,
October 2024 in “International Journal of Extreme Manufacturing” This review discusses the advancements and challenges in skin bioprinting techniques and applications, including hair follicles and pigmentation, while addressing the need for improvements in vascularization, safety, and clinical translation, according to the authors.
24 citations
,
February 2016 in “PubMed” This study found that royal jelly may have a cardioprotective effect against paclitaxel-induced damage in rats by reducing oxidative and nitrosative stress, lowering cardiac biomarker levels, and mitigating heart tissue injuries.
24 citations
,
July 2014 in “British Journal of Anaesthesia” Long surgeries can cause temporary hair loss due to pressure on the scalp.
24 citations
,
May 2013 in “Drug Design Development and Therapy” This pilot study found that a multimodal minoxidil microemulsion with diclofenac and tea tree oil was more effective and safer than minoxidil alone for treating androgenic alopecia over 32 weeks.
22 citations
,
October 2021 in “Dermatologic Therapy” This study found that approximately one-quarter of post-COVID-19 patients experienced telogen effluvium, with a higher incidence among women, hospitalized patients, and those with hypertension or respiratory symptoms.
21 citations
,
January 2015 in “Dental research journal” In this study, women with polycystic ovary syndrome were found to have a higher prevalence of periodontal diseases compared to healthy controls, possibly due to shared inflammatory mechanisms.
20 citations
,
May 2023 in “Biological Trace Element Research” This study found that repeated oral intake of 0.5 or 5 mg/kg of cobalt ferrite nanoparticles induced pulmonary toxicity in rats, with dose-dependent oxidative stress and inflammation observed, but no notable toxicity was seen at a 0.05 mg/kg dose.
20 citations
,
September 2019 in “South African Journal of Botany” This study found that Teucrium polium L. subsp. geyrii Maire extract demonstrated a large safety margin in acute and subacute toxicity tests on mice and significantly enhanced wound healing in rats, especially with callus extract, by improving cell proliferation and wound contraction.
19 citations
,
September 2020 in “Pharmaceutics” This study investigated a new formula called SV-loaded nanospanlastics for topical application to treat androgenic alopecia. It showed similar effectiveness to minoxidil lotion but with fewer adverse effects when used to enhance dermal delivery and efficacy of sodium valproate.
19 citations
,
April 2020 in “Dermatologic Therapy” This review found that dutasteride is more potent than finasteride as a dual receptor dihydrotestosterone blocker for treating androgenetic alopecia and shares a similar safety profile in terms of fertility, teratogenicity, neurotoxicity, and hepatotoxicity.
19 citations
,
July 2012 in “Biotechnic & Histochemistry” This study observed that decreased nucleolar organizing region protein synthesis in hair root cells is correlated with hair loss in humans.
19 citations
,
August 2008 in “Journal of The European Academy of Dermatology and Venereology” In this study, researchers observed that in advanced androgenetic alopecia, increased DNA damage in the frontal bald area may lead to cell apoptosis due to impaired repair capacity.
18 citations
,
January 2020 in “Acta dermato-venereologica” This overview discusses advancements in the understanding of molecular genetics in heritable keratinization disorders, focusing on recent cases of inherited ichthyosis, and reports no new clinical results.
17 citations
,
July 2019 in “Majalah Obat Tradisional” This study found that tannin effectively inhibits and degrades mono-species and polymicrobial biofilms, making it a potential candidate for antibiofilm treatments.