Is There Any Relationship Between Decreased AgNOR Protein Synthesis and Human Hair Loss?

The study, involving 21 healthy males, found a significant association between decreased synthesis of Argyrophilic nucleolar organizing region associated proteins (AgNORs) and hair loss. Hair root cells from areas of hair loss had lower AgNOR counts and AgNORa/TNa ratios compared to cells from normal hair sites. These findings suggest that a reduction in NOR protein synthesis may contribute to hair loss by affecting hair follicle development and ribosome biogenesis. The research highlights the importance of NOR proteins in hair growth and suggests that their decreased expression is linked to hair loss, warranting further investigation into the genetic factors of alopecia.